Zhen X - Search Results

1

Further SAR study on 11-O-substituted aporphine analogues: identification of highly potent dopamine D3 receptor ligands.

Ye N, Wu Q, Zhu L, Zheng L, Gao B, Zhen X, Zhang A. Ye N, et al. Among authors: zhen x. Bioorg Med Chem. 2011 Mar 15;19(6):1999-2008. doi: 10.1016/j.bmc.2011.01.053. Epub 2011 Jan 31. Bioorg Med Chem. 2011. PMID: 21334902

2

Synthesis of 5α-cholestan-6-one derivatives and their inhibitory activities of NO production in activated microglia: discovery of a novel neuroinflammation inhibitor.

Yang YX, Zheng LT, Shi JJ, Gao B, Chen YK, Yang HC, Chen HL, Li YC, Zhen XC. Yang YX, et al. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1222-7. doi: 10.1016/j.bmcl.2013.12.055. Epub 2013 Dec 19. Bioorg Med Chem Lett. 2014. PMID: 24456901

3

N-Propylnoraporphin-11-O-yl carboxylic esters as potent dopamine D(2) and serotonin 5-HT(1A) receptor dual ligands.

Liu Z, Chen X, Sun P, Yu L, Zhen X, Zhang A. Liu Z, et al. Among authors: zhen x. Bioorg Med Chem. 2008 Sep 15;16(18):8335-8. doi: 10.1016/j.bmc.2008.08.056. Epub 2008 Aug 28. Bioorg Med Chem. 2008. PMID: 18783955

4

Synthesis of 6-substituted 1-phenylbenzazepines and their dopamine D(1) receptor activities.

Zhang J, Chen X, Yu L, Zhen X, Zhang A. Zhang J, et al. Among authors: zhen x. Bioorg Med Chem. 2008 Nov 1;16(21):9425-31. doi: 10.1016/j.bmc.2008.09.049. Epub 2008 Sep 20. Bioorg Med Chem. 2008. PMID: 18835172

5

'Click' D(1) receptor agonists with a 5-HT(1A) receptor pharmacophore producing D(2) receptor activity.

Zhang J, Zhang H, Cai W, Yu L, Zhen X, Zhang A. Zhang J, et al. Among authors: zhen x. Bioorg Med Chem. 2009 Jul 15;17(14):4873-80. doi: 10.1016/j.bmc.2009.06.019. Epub 2009 Jun 16. Bioorg Med Chem. 2009. PMID: 19559623

6

Synthesis of dihydrofuroaporphine derivatives: identification of a potent and selective serotonin 5-HT 1A receptor agonist.

Liu Z, Zhang H, Ye N, Zhang J, Wu Q, Sun P, Li L, Zhen X, Zhang A. Liu Z, et al. Among authors: zhen x. J Med Chem. 2010 Feb 11;53(3):1319-28. doi: 10.1021/jm9015763. J Med Chem. 2010. PMID: 20041669

7

Identification of N-propylnoraporphin-11-yl 5-(1,2-dithiolan-3-yl)pentanoate as a new anti-Parkinson's agent possessing a dopamine D2 and serotonin 5-HT1A dual-agonist profile.

Zhang H, Ye N, Zhou S, Guo L, Zheng L, Liu Z, Gao B, Zhen X, Zhang A. Zhang H, et al. Among authors: zhen x. J Med Chem. 2011 Jul 14;54(13):4324-38. doi: 10.1021/jm200347t. Epub 2011 Jun 2. J Med Chem. 2011. PMID: 21591752

8

Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile.

Sun H, Zhu L, Yang H, Qian W, Guo L, Zhou S, Gao B, Li Z, Zhou Y, Jiang H, Chen K, Zhen X, Liu H. Sun H, et al. Among authors: zhen x. Bioorg Med Chem. 2013 Feb 15;21(4):856-68. doi: 10.1016/j.bmc.2012.12.016. Epub 2012 Dec 21. Bioorg Med Chem. 2013. PMID: 23332346

9

(6aR)-11-amino-N-propyl-noraporphine, a new dopamine D2 and serotonin 5-HT1A dual agonist, elicits potent antiparkinsonian action and attenuates levodopa-induced dyskinesia in a 6-OHDA-lesioned rat model of Parkinson's disease.

Zhao R, Lu W, Fang X, Guo L, Yang Z, Ye N, Zhao J, Liu Z, Jia J, Zheng L, Zhao B, Zhang A, Zhen X. Zhao R, et al. Among authors: zhen x. Pharmacol Biochem Behav. 2014 Sep;124:204-10. doi: 10.1016/j.pbb.2014.06.011. Epub 2014 Jun 21. Pharmacol Biochem Behav. 2014. PMID: 24955866

10

Structural manipulation on the catecholic fragment of dopamine D(1) receptor agonist 1-phenyl-N-methyl-benzazepines.

Zhang J, Huang J, Song Z, Guo L, Cai W, Wang Y, Zhen X, Zhang A. Zhang J, et al. Among authors: zhen x. Eur J Med Chem. 2014 Oct 6;85:16-26. doi: 10.1016/j.ejmech.2014.07.059. Epub 2014 Jul 24. Eur J Med Chem. 2014. PMID: 25076379

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