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Imidazo[1,5-a]pyrazines: orally efficacious inhibitors of mTORC1 and mTORC2.
Crew AP, Bhagwat SV, Dong H, Bittner MA, Chan A, Chen X, Coate H, Cooke A, Gokhale PC, Honda A, Jin M, Kahler J, Mantis C, Mulvihill MJ, Tavares-Greco PA, Volk B, Wang J, Werner DS, Arnold LD, Pachter JA, Wild R, Gibson NW. Crew AP, et al. Among authors: chen x. Bioorg Med Chem Lett. 2011 Apr 1;21(7):2092-7. doi: 10.1016/j.bmcl.2011.01.139. Epub 2011 Feb 3. Bioorg Med Chem Lett. 2011. PMID: 21353551
A highly effective one-pot synthesis of quinolines from o-nitroarylcarbaldehydes.
Li AH, Ahmed E, Chen X, Cox M, Crew AP, Dong HQ, Jin M, Ma L, Panicker B, Siu KW, Steinig AG, Stolz KM, Tavares PA, Volk B, Weng Q, Werner D, Mulvihill MJ. Li AH, et al. Among authors: chen x. Org Biomol Chem. 2007 Jan 7;5(1):61-4. doi: 10.1039/b613775j. Epub 2006 Nov 6. Org Biomol Chem. 2007. PMID: 17164907
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