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Sp1 is an essential transcription factor for LPS-induced tissue factor expression in THP-1 monocytic cells, and nobiletin represses the expression through inhibition of NF-kappaB, AP-1, and Sp1 activation.
Hirata Y, Masuda Y, Kakutani H, Higuchi T, Takada K, Ito A, Nakagawa Y, Ishii H. Hirata Y, et al. Among authors: ishii h. Biochem Pharmacol. 2008 Apr 1;75(7):1504-14. doi: 10.1016/j.bcp.2007.12.019. Epub 2008 Jan 5. Biochem Pharmacol. 2008. PMID: 18261712
Oxidized phospholipids in oxidized low-density lipoprotein down-regulate thrombomodulin transcription in vascular endothelial cells through a decrease in the binding of RARbeta-RXRalpha heterodimers and Sp1 and Sp3 to their binding sequences in the TM promoter.
Ishii H, Tezuka T, Ishikawa H, Takada K, Oida K, Horie S. Ishii H, et al. Blood. 2003 Jun 15;101(12):4765-74. doi: 10.1182/blood-2002-08-2428. Epub 2003 Feb 6. Blood. 2003. PMID: 12576329 Free article.
4,200 results