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Page 1
Enhancing antibody Fc heterodimer formation through electrostatic steering effects: applications to bispecific molecules and monovalent IgG.
Gunasekaran K, Pentony M, Shen M, Garrett L, Forte C, Woodward A, Ng SB, Born T, Retter M, Manchulenko K, Sweet H, Foltz IN, Wittekind M, Yan W. Gunasekaran K, et al. Among authors: foltz in. J Biol Chem. 2010 Jun 18;285(25):19637-46. doi: 10.1074/jbc.M110.117382. Epub 2010 Apr 16. J Biol Chem. 2010. PMID: 20400508 Free PMC article.
MEDI0639: a novel therapeutic antibody targeting Dll4 modulates endothelial cell function and angiogenesis in vivo.
Jenkins DW, Ross S, Veldman-Jones M, Foltz IN, Clavette BC, Manchulenko K, Eberlein C, Kendrew J, Petteruti P, Cho S, Damschroder M, Peng L, Baker D, Smith NR, Weir HM, Blakey DC, Bedian V, Barry ST. Jenkins DW, et al. Among authors: foltz in. Mol Cancer Ther. 2012 Aug;11(8):1650-60. doi: 10.1158/1535-7163.MCT-11-1027. Epub 2012 Jun 7. Mol Cancer Ther. 2012. PMID: 22679110
Pharmacology of AMG 181, a human anti-α4 β7 antibody that specifically alters trafficking of gut-homing T cells.
Pan WJ, Hsu H, Rees WA, Lear SP, Lee F, Foltz IN, Rathanaswami P, Manchulenko K, Chan BM, Zhang M, Xia XZ, Patel SK, Prince PJ, Doherty DR, Sheckler CM, Reynhardt KO, Krill CD, Harder BJ, Wisler JA, Brandvig JL, Lynch JL, Anderson AA, Wienkers LC, Borie DC. Pan WJ, et al. Among authors: foltz in. Br J Pharmacol. 2013 May;169(1):51-68. doi: 10.1111/bph.12134. Br J Pharmacol. 2013. PMID: 23425116 Free PMC article.
A novel antibody engineering strategy for making monovalent bispecific heterodimeric IgG antibodies by electrostatic steering mechanism.
Liu Z, Leng EC, Gunasekaran K, Pentony M, Shen M, Howard M, Stoops J, Manchulenko K, Razinkov V, Liu H, Fanslow W, Hu Z, Sun N, Hasegawa H, Clark R, Foltz IN, Yan W. Liu Z, et al. Among authors: foltz in. J Biol Chem. 2015 Mar 20;290(12):7535-62. doi: 10.1074/jbc.M114.620260. Epub 2015 Jan 12. J Biol Chem. 2015. PMID: 25583986 Free PMC article.
Impact of antibody subclass and disulfide isoform differences on the biological activity of CD200R and βklotho agonist antibodies.
Grujic O, Stevens J, Chou RY, Weiszmann JV, Sekirov L, Thomson C, Badh A, Grauer S, Chan B, Graham K, Manchulenko K, Dillon TM, Li Y, Foltz IN. Grujic O, et al. Among authors: foltz in. Biochem Biophys Res Commun. 2017 May 13;486(4):985-991. doi: 10.1016/j.bbrc.2017.03.145. Epub 2017 Mar 28. Biochem Biophys Res Commun. 2017. PMID: 28363871
Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer's disease.
Ellwanger DC, Wang S, Brioschi S, Shao Z, Green L, Case R, Yoo D, Weishuhn D, Rathanaswami P, Bradley J, Rao S, Cha D, Luan P, Sambashivan S, Gilfillan S, Hasson SA, Foltz IN, van Lookeren Campagne M, Colonna M. Ellwanger DC, et al. Among authors: foltz in. Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2017742118. doi: 10.1073/pnas.2017742118. Proc Natl Acad Sci U S A. 2021. PMID: 33446504 Free PMC article.
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