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Structural simplification of bioactive natural products with multicomponent synthesis. 3. Fused uracil-containing heterocycles as novel topoisomerase-targeting agents.
Evdokimov NM, Van Slambrouck S, Heffeter P, Tu L, Le Calvé B, Lamoral-Theys D, Hooten CJ, Uglinskii PY, Rogelj S, Kiss R, Steelant WF, Berger W, Yang JJ, Bologa CG, Kornienko A, Magedov IV. Evdokimov NM, et al. Among authors: van slambrouck s. J Med Chem. 2011 Apr 14;54(7):2012-21. doi: 10.1021/jm1009428. Epub 2011 Mar 9. J Med Chem. 2011. PMID: 21388138 Free PMC article.
Structural simplification of bioactive natural products with multicomponent synthesis: dihydropyridopyrazole analogues of podophyllotoxin.
Magedov IV, Manpadi M, Rozhkova E, Przheval'skii NM, Rogelj S, Shors ST, Steelant WF, Van slambrouck S, Kornienko A. Magedov IV, et al. Among authors: van slambrouck s. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1381-5. doi: 10.1016/j.bmcl.2006.11.095. Epub 2006 Dec 6. Bioorg Med Chem Lett. 2007. PMID: 17188868 Free PMC article.
Three-component synthesis and anticancer evaluation of polycyclic indenopyridines lead to the discovery of a novel indenoheterocycle with potent apoptosis inducing properties.
Manpadi M, Uglinskii PY, Rastogi SK, Cotter KM, Wong YS, Anderson LA, Ortega AJ, Van Slambrouck S, Steelant WF, Rogelj S, Tongwa P, Antipin MY, Magedov IV, Kornienko A. Manpadi M, et al. Among authors: van slambrouck s. Org Biomol Chem. 2007 Dec 7;5(23):3865-72. doi: 10.1039/b713820b. Epub 2007 Oct 24. Org Biomol Chem. 2007. PMID: 18004468
Structural simplification of bioactive natural products with multicomponent synthesis. 2. antiproliferative and antitubulin activities of pyrano[3,2-c]pyridones and pyrano[3,2-c]quinolones.
Magedov IV, Manpadi M, Ogasawara MA, Dhawan AS, Rogelj S, Van Slambrouck S, Steelant WF, Evdokimov NM, Uglinskii PY, Elias EM, Knee EJ, Tongwa P, Antipin MY, Kornienko A. Magedov IV, et al. Among authors: van slambrouck s. J Med Chem. 2008 Apr 24;51(8):2561-70. doi: 10.1021/jm701499n. Epub 2008 Mar 25. J Med Chem. 2008. PMID: 18361483 Free PMC article.
Inhibitory effects of ethacrynic acid analogues lacking the α,β-unsaturated carbonyl unit and para-acylated phenols on human cancer cells.
Bryant ZE, Janser RF, Jabarkhail M, Candelaria-Lyons MS, Romero BB, Van slambrouck S, Steelant WF, Janser I. Bryant ZE, et al. Among authors: van slambrouck s. Bioorg Med Chem Lett. 2011 Feb 1;21(3):912-5. doi: 10.1016/j.bmcl.2010.12.074. Epub 2010 Dec 19. Bioorg Med Chem Lett. 2011. PMID: 21227691 Free PMC article.
Anticancer properties of an important drug lead podophyllotoxin can be efficiently mimicked by diverse heterocyclic scaffolds accessible via one-step synthesis.
Magedov IV, Frolova L, Manpadi M, Bhoga Ud, Tang H, Evdokimov NM, George O, Georgiou KH, Renner S, Getlik M, Kinnibrugh TL, Fernandes MA, Van slambrouck S, Steelant WF, Shuster CB, Rogelj S, van Otterlo WA, Kornienko A. Magedov IV, et al. Among authors: van slambrouck s. J Med Chem. 2011 Jun 23;54(12):4234-46. doi: 10.1021/jm200410r. Epub 2011 May 26. J Med Chem. 2011. PMID: 21615090 Free PMC article.
Structural simplification of bioactive natural products with multicomponent synthesis. 4. 4H-pyrano-[2,3-b]naphthoquinones with anticancer activity.
Magedov IV, Kireev AS, Jenkins AR, Evdokimov NM, Lima DT, Tongwa P, Altig J, Steelant WF, Van slambrouck S, Antipin MY, Kornienko A. Magedov IV, et al. Among authors: van slambrouck s. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5195-8. doi: 10.1016/j.bmcl.2012.06.073. Epub 2012 Jul 4. Bioorg Med Chem Lett. 2012. PMID: 22819765 Free PMC article.
27 results