Mizuarai S - Search Results

1

MK-1775, a potent Wee1 inhibitor, synergizes with gemcitabine to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenografts.

Rajeshkumar NV, De Oliveira E, Ottenhof N, Watters J, Brooks D, Demuth T, Shumway SD, Mizuarai S, Hirai H, Maitra A, Hidalgo M. Rajeshkumar NV, et al. Among authors: mizuarai s. Clin Cancer Res. 2011 May 1;17(9):2799-806. doi: 10.1158/1078-0432.CCR-10-2580. Epub 2011 Mar 9. Clin Cancer Res. 2011. PMID: 21389100 Free PMC article.

2

Integrase-mediated nonviral gene transfection with enhanced integration efficiency.

Mizuarai S, Kamihira M, Nishijima K, Iijima S. Mizuarai S, et al. J Biosci Bioeng. 1999;88(5):461-7. doi: 10.1016/s1389-1723(00)87659-8. J Biosci Bioeng. 1999. PMID: 16232645

3

Amplification of competitive telomere sequence in living animal cells induces chromatin instability.

Mizuarai S, Nishijima K, Iijima S. Mizuarai S, et al. Cytotechnology. 1999 Sep;31(1-2):195-203. doi: 10.1023/A:1008088609398. Cytotechnology. 1999. PMID: 19003141 Free PMC article.

4

Production of transgenic quails with high frequency of germ-line transmission using VSV-G pseudotyped retroviral vector.

Mizuarai S, Ono K, Yamaguchi K, Nishijima K, Kamihira M, Iijima S. Mizuarai S, et al. Biochem Biophys Res Commun. 2001 Aug 24;286(3):456-63. doi: 10.1006/bbrc.2001.5422. Biochem Biophys Res Commun. 2001. PMID: 11511080

5

Discovery of gene expression-based pharmacodynamic biomarker for a p53 context-specific anti-tumor drug Wee1 inhibitor.

Mizuarai S, Yamanaka K, Itadani H, Arai T, Nishibata T, Hirai H, Kotani H. Mizuarai S, et al. Mol Cancer. 2009 Jun 8;8:34. doi: 10.1186/1476-4598-8-34. Mol Cancer. 2009. PMID: 19500427 Free PMC article.

6

Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents.

Hirai H, Iwasawa Y, Okada M, Arai T, Nishibata T, Kobayashi M, Kimura T, Kaneko N, Ohtani J, Yamanaka K, Itadani H, Takahashi-Suzuki I, Fukasawa K, Oki H, Nambu T, Jiang J, Sakai T, Arakawa H, Sakamoto T, Sagara T, Yoshizumi T, Mizuarai S, Kotani H. Hirai H, et al. Among authors: mizuarai s. Mol Cancer Ther. 2009 Nov;8(11):2992-3000. doi: 10.1158/1535-7163.MCT-09-0463. Epub 2009 Nov 3. Mol Cancer Ther. 2009. PMID: 19887545

7

MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil.

Hirai H, Arai T, Okada M, Nishibata T, Kobayashi M, Sakai N, Imagaki K, Ohtani J, Sakai T, Yoshizumi T, Mizuarai S, Iwasawa Y, Kotani H. Hirai H, et al. Among authors: mizuarai s. Cancer Biol Ther. 2010 Apr 1;9(7):514-22. doi: 10.4161/cbt.9.7.11115. Epub 2010 Apr 1. Cancer Biol Ther. 2010. PMID: 20107315 Free article.

8

TAS-119, a novel selective Aurora A and TRK inhibitor, exhibits antitumor efficacy in preclinical models with deregulated activation of the Myc, β-Catenin, and TRK pathways.

Miura A, Sootome H, Fujita N, Suzuki T, Fukushima H, Mizuarai S, Masuko N, Ito K, Hashimoto A, Uto Y, Sugimoto T, Takahashi H, Mitsuya M, Hirai H. Miura A, et al. Among authors: mizuarai s. Invest New Drugs. 2021 Jun;39(3):724-735. doi: 10.1007/s10637-020-01019-9. Epub 2021 Jan 6. Invest New Drugs. 2021. PMID: 33409897

9

Expression levels of NF-Y target genes changed by CDKN1B correlate with clinical prognosis in multiple cancers.

Yamanaka K, Mizuarai S, Eguchi T, Itadani H, Hirai H, Kotani H. Yamanaka K, et al. Among authors: mizuarai s. Genomics. 2009 Oct;94(4):219-27. doi: 10.1016/j.ygeno.2009.06.003. Epub 2009 Jun 25. Genomics. 2009. PMID: 19559782 Free article.

10

3'-ethynylcytidine, an RNA polymerase inhibitor, combined with cisplatin exhibits a potent synergistic growth-inhibitory effect via Vaults dysfunction.

Fukushima H, Abe T, Sakamoto K, Tsujimoto H, Mizuarai S, Oie S. Fukushima H, et al. Among authors: mizuarai s. BMC Cancer. 2014 Aug 4;14:562. doi: 10.1186/1471-2407-14-562. BMC Cancer. 2014. PMID: 25087851 Free PMC article.

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