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A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity.
Dong J, Sereno A, Aivazian D, Langley E, Miller BR, Snyder WB, Chan E, Cantele M, Morena R, Joseph IB, Boccia A, Virata C, Gamez J, Yco G, Favis M, Wu X, Graff CP, Wang Q, Rohde E, Rennard R, Berquist L, Huang F, Zhang Y, Gao SX, Ho SN, Demarest SJ, Reff ME, Hariharan K, Glaser SM. Dong J, et al. Among authors: ho sn. MAbs. 2011 May-Jun;3(3):273-88. doi: 10.4161/mabs.3.3.15188. Epub 2011 May 1. MAbs. 2011. PMID: 21393993 Free PMC article.
Characterization of inhibitory anti-insulin-like growth factor receptor antibodies with different epitope specificity and ligand-blocking properties: implications for mechanism of action in vivo.
Doern A, Cao X, Sereno A, Reyes CL, Altshuler A, Huang F, Hession C, Flavier A, Favis M, Tran H, Ailor E, Levesque M, Murphy T, Berquist L, Tamraz S, Snipas T, Garber E, Shestowsky WS, Rennard R, Graff CP, Wu X, Snyder W, Cole L, Gregson D, Shields M, Ho SN, Reff ME, Glaser SM, Dong J, Demarest SJ, Hariharan K. Doern A, et al. Among authors: ho sn. J Biol Chem. 2009 Apr 10;284(15):10254-67. doi: 10.1074/jbc.M809709200. Epub 2009 Feb 11. J Biol Chem. 2009. PMID: 19211557 Free PMC article.
Antibody-mediated blockade of integrin alpha v beta 6 inhibits tumor progression in vivo by a transforming growth factor-beta-regulated mechanism.
Van Aarsen LA, Leone DR, Ho S, Dolinski BM, McCoon PE, LePage DJ, Kelly R, Heaney G, Rayhorn P, Reid C, Simon KJ, Horan GS, Tao N, Gardner HA, Skelly MM, Gown AM, Thomas GJ, Weinreb PH, Fawell SE, Violette SM. Van Aarsen LA, et al. Cancer Res. 2008 Jan 15;68(2):561-70. doi: 10.1158/0008-5472.CAN-07-2307. Cancer Res. 2008. PMID: 18199553
Haematological setpoints are a stable and patient-specific deep phenotype.
Foy BH, Petherbridge R, Roth MT, Zhang C, De Souza DC, Mow C, Patel HR, Patel CH, Ho SN, Lam E, Powe CE, Hasserjian RP, Karczewski KJ, Tozzo V, Higgins JM. Foy BH, et al. Among authors: ho sn. Nature. 2024 Dec 11. doi: 10.1038/s41586-024-08264-5. Online ahead of print. Nature. 2024. PMID: 39663453
Computer vision quantitation of erythrocyte shape abnormalities provides diagnostic, prognostic, and mechanistic insight.
Foy BH, Stefely JA, Bendapudi PK, Hasserjian RP, Al-Samkari H, Louissaint A, Fitzpatrick MJ, Hutchison B, Mow C, Collins J, Patel HR, Patel CH, Patel N, Ho SN, Kaufman RM, Dzik WH, Higgins JM, Makar RS. Foy BH, et al. Among authors: ho sn. Blood Adv. 2023 Aug 22;7(16):4621-4630. doi: 10.1182/bloodadvances.2022008967. Blood Adv. 2023. PMID: 37146262 Free PMC article.
62 results