Varty G - Search Results

1

Potent and selective adenosine A(2A) receptor antagonists: [1,2,4]-triazolo[4,3-c]pyrimidin-3-ones.

Harris JM, Neustadt BR, Zhang H, Lachowicz J, Cohen-Williams M, Varty G, Hao J, Stamford AW. Harris JM, et al. Among authors: varty g. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2497-501. doi: 10.1016/j.bmcl.2011.02.045. Epub 2011 Feb 24. Bioorg Med Chem Lett. 2011. PMID: 21398125

2

Potent and selective adenosine A2A receptor antagonists: 1,2,4-Triazolo[1,5-c]pyrimidines.

Neustadt BR, Liu H, Hao J, Greenlee WJ, Stamford AW, Foster C, Arik L, Lachowicz J, Zhang H, Bertorelli R, Fredduzzi S, Varty G, Cohen-Williams M, Ng K. Neustadt BR, et al. Among authors: varty g. Bioorg Med Chem Lett. 2009 Feb 1;19(3):967-71. doi: 10.1016/j.bmcl.2008.11.075. Epub 2008 Nov 24. Bioorg Med Chem Lett. 2009. PMID: 19109019

3

Discovery of a series of potent, orally active α,α-disubstituted piperidine NK(1) antagonists.

Xiao D, Wang C, Palani A, Tsui HC, Reichard G, Paliwal S, Shih NY, Aslanian R, Duffy R, Lachowicz J, Varty G, Morgan C, Liu F, Nomeir A. Xiao D, et al. Among authors: varty g. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6313-5. doi: 10.1016/j.bmcl.2010.08.059. Epub 2010 Aug 15. Bioorg Med Chem Lett. 2010. PMID: 20846861

4

2-(2-Furanyl)-7-phenyl[1,2,4]triazolo[1,5-c]pyrimidin-5-amine analogs: highly potent, orally active, adenosine A2A antagonists. Part 1.

Matasi JJ, Caldwell JP, Zhang H, Fawzi A, Cohen-Williams ME, Varty GB, Tulshian DB. Matasi JJ, et al. Bioorg Med Chem Lett. 2005 Aug 15;15(16):3670-4. doi: 10.1016/j.bmcl.2005.05.086. Bioorg Med Chem Lett. 2005. PMID: 15978806

5

2-(2-Furanyl)-7-phenyl[1,2,4]triazolo[1,5-c]pyrimidin-5-amine analogs as adenosine A2A antagonists: the successful reduction of hERG activity. Part 2.

Matasi JJ, Caldwell JP, Zhang H, Fawzi A, Higgins GA, Cohen-Williams ME, Varty GB, Tulshian DB. Matasi JJ, et al. Bioorg Med Chem Lett. 2005 Aug 15;15(16):3675-8. doi: 10.1016/j.bmcl.2005.05.043. Bioorg Med Chem Lett. 2005. PMID: 15982882

6

Cyclic urea derivatives as potent NK1 selective antagonists.

Shue HJ, Chen X, Shih NY, Blythin DJ, Paliwal S, Lin L, Gu D, Schwerdt JH, Shah S, Reichard GA, Piwinski JJ, Duffy RA, Lachowicz JE, Coffin VL, Liu F, Nomeir AA, Morgan CA, Varty GB. Shue HJ, et al. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3896-9. doi: 10.1016/j.bmcl.2005.05.111. Bioorg Med Chem Lett. 2005. PMID: 16019209

7

Cyclic urea derivatives as potent NK1 selective antagonists. Part II: Effects of fluoro and benzylic methyl substitutions.

Shue HJ, Chen X, Schwerdt JH, Paliwal S, Blythin DJ, Lin L, Gu D, Wang C, Reichard GA, Wang H, Piwinski JJ, Duffy RA, Lachowicz JE, Coffin VL, Nomeir AA, Morgan CA, Varty GB, Shih NY. Shue HJ, et al. Bioorg Med Chem Lett. 2006 Feb 15;16(4):1065-9. doi: 10.1016/j.bmcl.2005.10.072. Epub 2005 Nov 14. Bioorg Med Chem Lett. 2006. PMID: 16290143

8

Cyclobutane derivatives as potent NK1 selective antagonists.

Wrobleski ML, Reichard GA, Paliwal S, Shah S, Tsui HC, Duffy RA, Lachowicz JE, Morgan CA, Varty GB, Shih NY. Wrobleski ML, et al. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3859-63. doi: 10.1016/j.bmcl.2006.04.031. Epub 2006 May 8. Bioorg Med Chem Lett. 2006. PMID: 16682196

9

Discovery of a novel, potent and orally active series of gamma-lactams as selective NK1 antagonists.

Paliwal S, Reichard GA, Shah S, Wrobleski ML, Wang C, Stengone C, Tsui HC, Xiao D, Duffy RA, Lachowicz JE, Nomeir AA, Varty GB, Shih NY. Paliwal S, et al. Bioorg Med Chem Lett. 2008 Jul 15;18(14):4168-71. doi: 10.1016/j.bmcl.2008.05.082. Epub 2008 May 24. Bioorg Med Chem Lett. 2008. PMID: 18547807

10

Design, synthesis, and evaluation of fused heterocyclic analogs of SCH 58261 as adenosine A2A receptor antagonists.

Shah U, Lankin CM, Boyle CD, Chackalamannil S, Greenlee WJ, Neustadt BR, Cohen-Williams ME, Higgins GA, Ng K, Varty GB, Zhang H, Lachowicz JE. Shah U, et al. Bioorg Med Chem Lett. 2008 Jul 15;18(14):4204-9. doi: 10.1016/j.bmcl.2008.05.069. Epub 2008 May 22. Bioorg Med Chem Lett. 2008. PMID: 18558486

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