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Map2k4 functions as a tumor suppressor in lung adenocarcinoma and inhibits tumor cell invasion by decreasing peroxisome proliferator-activated receptor γ2 expression.
Ahn YH, Yang Y, Gibbons DL, Creighton CJ, Yang F, Wistuba II, Lin W, Thilaganathan N, Alvarez CA, Roybal J, Goldsmith EJ, Tournier C, Kurie JM. Ahn YH, et al. Among authors: lin w. Mol Cell Biol. 2011 Nov;31(21):4270-85. doi: 10.1128/MCB.05562-11. Epub 2011 Sep 6. Mol Cell Biol. 2011. PMID: 21896780 Free PMC article.
Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression.
Chen L, Gibbons DL, Goswami S, Cortez MA, Ahn YH, Byers LA, Zhang X, Yi X, Dwyer D, Lin W, Diao L, Wang J, Roybal J, Patel M, Ungewiss C, Peng D, Antonia S, Mediavilla-Varela M, Robertson G, Suraokar M, Welsh JW, Erez B, Wistuba II, Chen L, Peng D, Wang S, Ullrich SE, Heymach JV, Kurie JM, Qin FX. Chen L, et al. Among authors: lin w. Nat Commun. 2014 Oct 28;5:5241. doi: 10.1038/ncomms6241. Nat Commun. 2014. PMID: 25348003 Free PMC article.
CD137 promotes proliferation and survival of human B cells.
Zhang X, Voskens CJ, Sallin M, Maniar A, Montes CL, Zhang Y, Lin W, Li G, Burch E, Tan M, Hertzano R, Chapoval AI, Tamada K, Gastman BR, Schulze DH, Strome SE. Zhang X, et al. Among authors: lin w. J Immunol. 2010 Jan 15;184(2):787-95. doi: 10.4049/jimmunol.0901619. Epub 2009 Dec 11. J Immunol. 2010. PMID: 20008291
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