Tourwé D - Search Results

1

Design of novel neurokinin 1 receptor antagonists based on conformationally constrained aromatic amino acids and discovery of a potent chimeric opioid agonist-neurokinin 1 receptor antagonist.

Ballet S, Feytens D, Buysse K, Chung NN, Lemieux C, Tumati S, Keresztes A, Van Duppen J, Lai J, Varga E, Porreca F, Schiller PW, Vanden Broeck J, Tourwé D. Ballet S, et al. Among authors: tourwe d. J Med Chem. 2011 Apr 14;54(7):2467-76. doi: 10.1021/jm1016285. Epub 2011 Mar 17. J Med Chem. 2011. PMID: 21413804 Free PMC article.

2

Conformational restriction of Tyr and Phe side chains in opioid peptides: information about preferred and bioactive side-chain topology.

Tourwé D, Verschueren K, Frycia A, Davis P, Porreca F, Hruby VJ, Toth G, Jaspers H, Verheyden P, Van Binst G. Tourwé D, et al. Biopolymers. 1996 Jan;38(1):1-12. doi: 10.1002/(sici)1097-0282(199601)38:1<1::aid-bip1>3.0.co;2-#. Biopolymers. 1996. PMID: 8679939

3

Conformationally constrained deltorphin analogs with 2-aminotetralin-2-carboxylic acid in position 3.

Tóth G, Darula Z, Péter A, Fülöp F, Tourwé D, Jaspers H, Verheyden P, Böcskey Z, Tóth Z, Borsodi A. Tóth G, et al. Among authors: tourwe d. J Med Chem. 1997 Mar 14;40(6):990-5. doi: 10.1021/jm9602726. J Med Chem. 1997. PMID: 9083489

4

Side chain methyl substitution in the delta-opioid receptor antagonist TIPP has an important effect on the activity profile.

Tourwé D, Mannekens E, Diem TN, Verheyden P, Jaspers H, Tóth G, Péter A, Kertész I, Török G, Chung NN, Schiller PW. Tourwé D, et al. J Med Chem. 1998 Dec 17;41(26):5167-76. doi: 10.1021/jm981011u. J Med Chem. 1998. PMID: 9857087

5

Probing opioid receptor interactions with azacycloalkane amino acids. Synthesis of a potent and selective ORL1 antagonist.

Halab L, Becker JA, Darula Z, Tourwé D, Kieffer BL, Simonin F, Lubell WD. Halab L, et al. Among authors: tourwe d. J Med Chem. 2002 Nov 21;45(24):5353-7. doi: 10.1021/jm020078l. J Med Chem. 2002. PMID: 12431062

6

Amide analogues of TSA: synthesis, binding mode analysis and HDAC inhibition.

Van Ommeslaeghe K, Elaut G, Brecx V, Papeleu P, Iterbeke K, Geerlings P, Tourwé D, Rogiers V. Van Ommeslaeghe K, et al. Among authors: tourwe d. Bioorg Med Chem Lett. 2003 Jun 2;13(11):1861-4. doi: 10.1016/s0960-894x(03)00284-1. Bioorg Med Chem Lett. 2003. PMID: 12749885

7

Structure-activity study on the Phe side chain arrangement of endomorphins using conformationally constrained analogues.

Tömböly C, Kövér KE, Péter A, Tourwé D, Biyashev D, Benyhe S, Borsodi A, Al-Khrasani M, Rónai AZ, Tóth G. Tömböly C, et al. Among authors: tourwe d. J Med Chem. 2004 Jan 29;47(3):735-43. doi: 10.1021/jm0310028. J Med Chem. 2004. PMID: 14736254

8

Structure-activity study of the ORL1 antagonist Ac-Arg-D-Cha-Qaa-D-Arg-D-p-ClPhe-NH2.

Van Cauwenberghe S, Simonin F, Cluzeau J, Becker JA, Lubell WD, Tourwé D. Van Cauwenberghe S, et al. Among authors: tourwe d. J Med Chem. 2004 Mar 25;47(7):1864-7. doi: 10.1021/jm031034v. J Med Chem. 2004. PMID: 15027881

9

Theoretical study revealing the functioning of a novel combination of catalytic motifs in histone deacetylase.

Vanommeslaeghe K, De Proft F, Loverix S, Tourwé D, Geerlings P. Vanommeslaeghe K, et al. Among authors: tourwe d. Bioorg Med Chem. 2005 Jun 2;13(12):3987-92. doi: 10.1016/j.bmc.2005.04.001. Bioorg Med Chem. 2005. PMID: 15878665

10

A new structural motif for mu-opioid antagonists.

Van den Eynde I, Laus G, Schiller PW, Kosson P, Chung NN, Lipkowski AW, Tourwé D. Van den Eynde I, et al. Among authors: tourwe d. J Med Chem. 2005 May 19;48(10):3644-8. doi: 10.1021/jm0491795. J Med Chem. 2005. PMID: 15887972

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