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Synthesis and biological evaluation of novel dimethyl[1,1'-biphenyl]-2,2'-dicarboxylate derivatives containing thiazolidine-2,4-dione for the treatment of concanavalin A-induced acute liver injury of BALB/c mice.
Wang G, Deng C, Xie C, Ma L, Yang J, Qiu N, Xu Q, Chen T, Peng F, Chen J, Qiu J, Peng A, Wei Y, Chen L. Wang G, et al. Eur J Med Chem. 2011 Dec;46(12):5941-8. doi: 10.1016/j.ejmech.2011.10.005. Epub 2011 Oct 8. Eur J Med Chem. 2011. PMID: 22019226
A novel small molecule, (E)-5-(2,4-di-tert-butyl-6-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)-5'-methyl-7,7'-dimethoxy-4,4'-bibenzo[d][1,3]dioxole-5,5'-dicarboxylate (7k), alleviates the development of D-galactosamine/lipopolysaccharide-induced acute liver failure by inhibiting macrophage infiltration and regulating cytokine expression.
Deng C, Liu J, Wang G, Ma L, Xie C, Wang X, Li X, Chen L. Deng C, et al. Among authors: wang x, wang g. J Pharmacol Exp Ther. 2012 Apr;341(1):146-55. doi: 10.1124/jpet.111.189498. Epub 2012 Jan 11. J Pharmacol Exp Ther. 2012. PMID: 22238210
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