Gerard M - Search Results

1

Blockade of enzyme activity inhibits tissue transglutaminase-mediated transamidation of α-synuclein in a cellular model of Parkinson's disease.

Verhaar R, Jongenelen CA, Gerard M, Baekelandt V, Van Dam AM, Wilhelmus MM, Drukarch B. Verhaar R, et al. Among authors: gerard m. Neurochem Int. 2011 Jun;58(7):785-93. doi: 10.1016/j.neuint.2011.03.004. Epub 2011 Mar 31. Neurochem Int. 2011. PMID: 21440023

2

FK506 binding protein 12 differentially accelerates fibril formation of wild type alpha-synuclein and its clinical mutants A30P or A53T.

Gerard M, Debyser Z, Desender L, Baert J, Brandt I, Baekelandt V, Engelborghs Y. Gerard M, et al. J Neurochem. 2008 Jul;106(1):121-33. doi: 10.1111/j.1471-4159.2008.05342.x. Epub 2008 Jul 1. J Neurochem. 2008. PMID: 18346205 Free article.

3

The remarkable conformational plasticity of alpha-synuclein: blessing or curse?

Deleersnijder A, Gerard M, Debyser Z, Baekelandt V. Deleersnijder A, et al. Among authors: gerard m. Trends Mol Med. 2013 Jun;19(6):368-77. doi: 10.1016/j.molmed.2013.04.002. Epub 2013 May 3. Trends Mol Med. 2013. PMID: 23648364 Review.

4

High-content analysis of α-synuclein aggregation and cell death in a cellular model of Parkinson's disease.

Macchi F, Deleersnijder A, Van den Haute C, Munck S, Pottel H, Michiels A, Debyser Z, Gerard M, Baekelandt V. Macchi F, et al. Among authors: gerard m. J Neurosci Methods. 2016 Mar 1;261:117-27. doi: 10.1016/j.jneumeth.2015.11.009. Epub 2015 Nov 24. J Neurosci Methods. 2016. PMID: 26620202

5

In vitro phosphorylation does not influence the aggregation kinetics of WT α-synuclein in contrast to its phosphorylation mutants.

Schreurs S, Gerard M, Derua R, Waelkens E, Taymans JM, Baekelandt V, Engelborghs Y. Schreurs S, et al. Among authors: gerard m. Int J Mol Sci. 2014 Jan 15;15(1):1040-67. doi: 10.3390/ijms15011040. Int J Mol Sci. 2014. PMID: 24434619 Free PMC article.

6

Inhibition of FK506 binding proteins reduces alpha-synuclein aggregation and Parkinson's disease-like pathology.

Gerard M, Deleersnijder A, Daniëls V, Schreurs S, Munck S, Reumers V, Pottel H, Engelborghs Y, Van den Haute C, Taymans JM, Debyser Z, Baekelandt V. Gerard M, et al. J Neurosci. 2010 Feb 17;30(7):2454-63. doi: 10.1523/JNEUROSCI.5983-09.2010. J Neurosci. 2010. PMID: 20164329 Free PMC article.

7

Comparative analysis of different peptidyl-prolyl isomerases reveals FK506-binding protein 12 as the most potent enhancer of alpha-synuclein aggregation.

Deleersnijder A, Van Rompuy AS, Desender L, Pottel H, Buée L, Debyser Z, Baekelandt V, Gerard M. Deleersnijder A, et al. Among authors: gerard m. J Biol Chem. 2011 Jul 29;286(30):26687-701. doi: 10.1074/jbc.M110.182303. Epub 2011 Jun 7. J Biol Chem. 2011. PMID: 21652707 Free PMC article.

8

A prolyl oligopeptidase inhibitor, KYP-2047, reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease.

Myöhänen TT, Hannula MJ, Van Elzen R, Gerard M, Van Der Veken P, García-Horsman JA, Baekelandt V, Männistö PT, Lambeir AM. Myöhänen TT, et al. Among authors: gerard m. Br J Pharmacol. 2012 Jun;166(3):1097-113. doi: 10.1111/j.1476-5381.2012.01846.x. Br J Pharmacol. 2012. PMID: 22233220 Free PMC article.

9

P2-substituted N-acylprolylpyrrolidine inhibitors of prolyl oligopeptidase: biochemical evaluation, binding mode determination, and assessment in a cellular model of synucleinopathy.

Van der Veken P, Fülöp V, Rea D, Gerard M, Van Elzen R, Joossens J, Cheng JD, Baekelandt V, De Meester I, Lambeir AM, Augustyns K. Van der Veken P, et al. Among authors: gerard m. J Med Chem. 2012 Nov 26;55(22):9856-67. doi: 10.1021/jm301060g. Epub 2012 Nov 13. J Med Chem. 2012. PMID: 23121075

10

The conformation and the aggregation kinetics of α-synuclein depend on the proline residues in its C-terminal region.

Meuvis J, Gerard M, Desender L, Baekelandt V, Engelborghs Y. Meuvis J, et al. Among authors: gerard m. Biochemistry. 2010 Nov 2;49(43):9345-52. doi: 10.1021/bi1010927. Biochemistry. 2010. PMID: 20828147

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