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Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?
Wang H, Dharmalingam P, Vasquez V, Mitra J, Boldogh I, Rao KS, Kent TA, Mitra S, Hegde ML. Wang H, et al. Among authors: rao ks. Mech Ageing Dev. 2017 Jan;161(Pt A):163-176. doi: 10.1016/j.mad.2016.09.005. Epub 2016 Sep 20. Mech Ageing Dev. 2017. PMID: 27663141 Free PMC article. Review.
Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects.
Mitra J, Guerrero EN, Hegde PM, Liachko NF, Wang H, Vasquez V, Gao J, Pandey A, Taylor JP, Kraemer BC, Wu P, Boldogh I, Garruto RM, Mitra S, Rao KS, Hegde ML. Mitra J, et al. Among authors: rao ks. Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4696-4705. doi: 10.1073/pnas.1818415116. Epub 2019 Feb 15. Proc Natl Acad Sci U S A. 2019. PMID: 30770445 Free PMC article.
736 results