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Single-molecule imaging and fluorescence lifetime imaging microscopy show different structures for high- and low-affinity epidermal growth factor receptors in A431 cells.
Webb SE, Roberts SK, Needham SR, Tynan CJ, Rolfe DJ, Winn MD, Clarke DT, Barraclough R, Martin-Fernandez ML. Webb SE, et al. Among authors: clarke dt. Biophys J. 2008 Feb 1;94(3):803-19. doi: 10.1529/biophysj.107.112623. Epub 2007 Sep 21. Biophys J. 2008. PMID: 17890389 Free PMC article.
EGFR oligomerization organizes kinase-active dimers into competent signalling platforms.
Needham SR, Roberts SK, Arkhipov A, Mysore VP, Tynan CJ, Zanetti-Domingues LC, Kim ET, Losasso V, Korovesis D, Hirsch M, Rolfe DJ, Clarke DT, Winn MD, Lajevardipour A, Clayton AH, Pike LJ, Perani M, Parker PJ, Shan Y, Shaw DE, Martin-Fernandez ML. Needham SR, et al. Among authors: clarke dt. Nat Commun. 2016 Oct 31;7:13307. doi: 10.1038/ncomms13307. Nat Commun. 2016. PMID: 27796308 Free PMC article.
The architecture of EGFR's basal complexes reveals autoinhibition mechanisms in dimers and oligomers.
Zanetti-Domingues LC, Korovesis D, Needham SR, Tynan CJ, Sagawa S, Roberts SK, Kuzmanic A, Ortiz-Zapater E, Jain P, Roovers RC, Lajevardipour A, van Bergen En Henegouwen PMP, Santis G, Clayton AHA, Clarke DT, Gervasio FL, Shan Y, Shaw DE, Rolfe DJ, Parker PJ, Martin-Fernandez ML. Zanetti-Domingues LC, et al. Among authors: clarke dt. Nat Commun. 2018 Oct 18;9(1):4325. doi: 10.1038/s41467-018-06632-0. Nat Commun. 2018. PMID: 30337523 Free PMC article.
61 results