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Peripheral cannabinoid-1 receptor inverse agonism reduces obesity by reversing leptin resistance.
Tam J, Cinar R, Liu J, Godlewski G, Wesley D, Jourdan T, Szanda G, Mukhopadhyay B, Chedester L, Liow JS, Innis RB, Cheng K, Rice KC, Deschamps JR, Chorvat RJ, McElroy JF, Kunos G. Tam J, et al. Among authors: godlewski g. Cell Metab. 2012 Aug 8;16(2):167-79. doi: 10.1016/j.cmet.2012.07.002. Epub 2012 Jul 26. Cell Metab. 2012. PMID: 22841573 Free PMC article.
The endogenous brain constituent N-arachidonoyl L-serine is an activator of large conductance Ca2+-activated K+ channels.
Godlewski G, Offertáler L, Osei-Hyiaman D, Mo FM, Harvey-White J, Liu J, Davis MI, Zhang L, Razdan RK, Milman G, Pacher P, Mukhopadhyay P, Lovinger DM, Kunos G. Godlewski G, et al. J Pharmacol Exp Ther. 2009 Jan;328(1):351-61. doi: 10.1124/jpet.108.144717. Epub 2008 Oct 15. J Pharmacol Exp Ther. 2009. PMID: 18923087 Free PMC article.
Transcriptional regulation of cannabinoid receptor-1 expression in the liver by retinoic acid acting via retinoic acid receptor-gamma.
Mukhopadhyay B, Liu J, Osei-Hyiaman D, Godlewski G, Mukhopadhyay P, Wang L, Jeong WI, Gao B, Duester G, Mackie K, Kojima S, Kunos G. Mukhopadhyay B, et al. Among authors: godlewski g. J Biol Chem. 2010 Jun 18;285(25):19002-11. doi: 10.1074/jbc.M109.068460. Epub 2010 Apr 21. J Biol Chem. 2010. PMID: 20410309 Free PMC article.
Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects.
Godlewski G, Alapafuja SO, Bátkai S, Nikas SP, Cinar R, Offertáler L, Osei-Hyiaman D, Liu J, Mukhopadhyay B, Harvey-White J, Tam J, Pacak K, Blankman JL, Cravatt BF, Makriyannis A, Kunos G. Godlewski G, et al. Chem Biol. 2010 Nov 24;17(11):1256-66. doi: 10.1016/j.chembiol.2010.08.013. Chem Biol. 2010. PMID: 21095576 Free PMC article.
Receptors for acylethanolamides-GPR55 and GPR119.
Godlewski G, Offertáler L, Wagner JA, Kunos G. Godlewski G, et al. Prostaglandins Other Lipid Mediat. 2009 Sep;89(3-4):105-11. doi: 10.1016/j.prostaglandins.2009.07.001. Epub 2009 Jul 15. Prostaglandins Other Lipid Mediat. 2009. PMID: 19615459 Free PMC article. Review.
196 results