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The endogenous brain constituent N-arachidonoyl L-serine is an activator of large conductance Ca2+-activated K+ channels.
Godlewski G, Offertáler L, Osei-Hyiaman D, Mo FM, Harvey-White J, Liu J, Davis MI, Zhang L, Razdan RK, Milman G, Pacher P, Mukhopadhyay P, Lovinger DM, Kunos G. Godlewski G, et al. Among authors: zhang l. J Pharmacol Exp Ther. 2009 Jan;328(1):351-61. doi: 10.1124/jpet.108.144717. Epub 2008 Oct 15. J Pharmacol Exp Ther. 2009. PMID: 18923087 Free PMC article.
Mutations M287L and Q266I in the glycine receptor α1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but not the minimal alveolar concentration in knockin mice.
Borghese CM, Xiong W, Oh SI, Ho A, Mihic SJ, Zhang L, Lovinger DM, Homanics GE, Eger EI 2nd, Harris RA. Borghese CM, et al. Among authors: zhang l. Anesthesiology. 2012 Oct;117(4):765-71. doi: 10.1097/ALN.0b013e31826a0d93. Anesthesiology. 2012. PMID: 22885675 Free PMC article.
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