Germino GG - Search Results

1

Ectopic expression of Cux1 is associated with reduced p27 expression and increased apoptosis during late stage cyst progression upon inactivation of Pkd1 in collecting ducts.

Paul BM, Vassmer D, Taylor A, Magenheimer L, Carlton CG, Piontek KB, Germino GG, Vanden Heuvel GB. Paul BM, et al. Among authors: germino gg. Dev Dyn. 2011 Jun;240(6):1493-501. doi: 10.1002/dvdy.22625. Epub 2011 Apr 4. Dev Dyn. 2011. PMID: 21465620 Free PMC article.

2

An unusual pattern of mutation in the duplicated portion of PKD1 is revealed by use of a novel strategy for mutation detection.

Watnick TJ, Piontek KB, Cordal TM, Weber H, Gandolph MA, Qian F, Lens XM, Neumann HP, Germino GG. Watnick TJ, et al. Among authors: germino gg. Hum Mol Genet. 1997 Sep;6(9):1473-81. doi: 10.1093/hmg/6.9.1473. Hum Mol Genet. 1997. PMID: 9285784

3

Murine Pkd1 introns 21 and 22 lack the extreme polypyrimidine bias present in human PKD1.

Piontek KB, Germino GG. Piontek KB, et al. Among authors: germino gg. Mamm Genome. 1999 Feb;10(2):194-6. doi: 10.1007/s003359900969. Mamm Genome. 1999. PMID: 9922404 No abstract available.

4

Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents.

Hanaoka K, Qian F, Boletta A, Bhunia AK, Piontek K, Tsiokas L, Sukhatme VP, Guggino WB, Germino GG. Hanaoka K, et al. Among authors: germino gg. Nature. 2000 Dec 21-28;408(6815):990-4. doi: 10.1038/35050128. Nature. 2000. PMID: 11140688

5

PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2.

Bhunia AK, Piontek K, Boletta A, Liu L, Qian F, Xu PN, Germino FJ, Germino GG. Bhunia AK, et al. Among authors: germino fj, germino gg. Cell. 2002 Apr 19;109(2):157-68. doi: 10.1016/s0092-8674(02)00716-x. Cell. 2002. PMID: 12007403 Free article.

6

A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo.

Piontek KB, Huso DL, Grinberg A, Liu L, Bedja D, Zhao H, Gabrielson K, Qian F, Mei C, Westphal H, Germino GG. Piontek KB, et al. Among authors: germino gg. J Am Soc Nephrol. 2004 Dec;15(12):3035-43. doi: 10.1097/01.ASN.0000144204.01352.86. J Am Soc Nephrol. 2004. PMID: 15579506

7

Loss of polycystin-1 or polycystin-2 results in dysregulated apolipoprotein expression in murine tissues via alterations in nuclear hormone receptors.

Allen E, Piontek KB, Garrett-Mayer E, Garcia-Gonzalez M, Gorelick KL, Germino GG. Allen E, et al. Among authors: germino gg. Hum Mol Genet. 2006 Jan 1;15(1):11-21. doi: 10.1093/hmg/ddi421. Epub 2005 Nov 21. Hum Mol Genet. 2006. PMID: 16301212 Free PMC article.

8

The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease.

Shillingford JM, Murcia NS, Larson CH, Low SH, Hedgepeth R, Brown N, Flask CA, Novick AC, Goldfarb DA, Kramer-Zucker A, Walz G, Piontek KB, Germino GG, Weimbs T. Shillingford JM, et al. Among authors: germino gg. Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5466-71. doi: 10.1073/pnas.0509694103. Epub 2006 Mar 27. Proc Natl Acad Sci U S A. 2006. PMID: 16567633 Free PMC article.

9

Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway.

Garcia-Gonzalez MA, Menezes LF, Piontek KB, Kaimori J, Huso DL, Watnick T, Onuchic LF, Guay-Woodford LM, Germino GG. Garcia-Gonzalez MA, et al. Among authors: germino gg. Hum Mol Genet. 2007 Aug 15;16(16):1940-50. doi: 10.1093/hmg/ddm141. Epub 2007 Jun 16. Hum Mol Genet. 2007. PMID: 17575307 Free PMC article.

10

A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1.

Piontek K, Menezes LF, Garcia-Gonzalez MA, Huso DL, Germino GG. Piontek K, et al. Among authors: germino gg. Nat Med. 2007 Dec;13(12):1490-5. doi: 10.1038/nm1675. Epub 2007 Oct 28. Nat Med. 2007. PMID: 17965720 Free PMC article.

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