Uchida K - Search Results

1

Lipid peroxidation modification of protein generates Nepsilon-(4-oxononanoyl)lysine as a pro-inflammatory ligand.

Shibata T, Shimozu Y, Wakita C, Shibata N, Kobayashi M, Machida S, Kato R, Itabe H, Zhu X, Sayre LM, Uchida K. Shibata T, et al. Among authors: uchida k. J Biol Chem. 2011 Jun 3;286(22):19943-57. doi: 10.1074/jbc.M110.187047. Epub 2011 Apr 6. J Biol Chem. 2011. PMID: 21471194 Free PMC article.

2

A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway.

Morimitsu Y, Nakagawa Y, Hayashi K, Fujii H, Kumagai T, Nakamura Y, Osawa T, Horio F, Itoh K, Iida K, Yamamoto M, Uchida K. Morimitsu Y, et al. Among authors: uchida k. J Biol Chem. 2002 Feb 1;277(5):3456-63. doi: 10.1074/jbc.M110244200. Epub 2001 Nov 12. J Biol Chem. 2002. PMID: 11706044 Free article.

We have recently developed a cell culture system, using rat liver epithelial RL 34 cells, that potently responds to the phenolic antioxidants resulting in the induction of GST activity (Kawamoto, Y., Nakamura, Y., Naito, Y., Torii, Y., Kumagai, T., Osawa, T., Ohigashi, H., Satoh, …

We have recently developed a cell culture system, using rat liver epithelial RL 34 cells, that potently responds to the phenolic antioxidant …

3

Ebselen, a glutathione peroxidase mimetic seleno-organic compound, as a multifunctional antioxidant. Implication for inflammation-associated carcinogenesis.

Nakamura Y, Feng Q, Kumagai T, Torikai K, Ohigashi H, Osawa T, Noguchi N, Niki E, Uchida K. Nakamura Y, et al. Among authors: uchida k. J Biol Chem. 2002 Jan 25;277(4):2687-94. doi: 10.1074/jbc.M109641200. Epub 2001 Nov 19. J Biol Chem. 2002. PMID: 11714717 Free article.

4

Involvement of the mitochondrial death pathway in chemopreventive benzyl isothiocyanate-induced apoptosis.

Nakamura Y, Kawakami M, Yoshihiro A, Miyoshi N, Ohigashi H, Kawai K, Osawa T, Uchida K. Nakamura Y, et al. Among authors: uchida k. J Biol Chem. 2002 Mar 8;277(10):8492-9. doi: 10.1074/jbc.M109760200. Epub 2001 Dec 20. J Biol Chem. 2002. PMID: 11751909 Free article.

5

15-deoxy-delta 12,14-prostaglandin J2. A prostaglandin D2 metabolite generated during inflammatory processes.

Shibata T, Kondo M, Osawa T, Shibata N, Kobayashi M, Uchida K. Shibata T, et al. Among authors: uchida k. J Biol Chem. 2002 Mar 22;277(12):10459-66. doi: 10.1074/jbc.M110314200. Epub 2002 Jan 10. J Biol Chem. 2002. PMID: 11786541 Free article.

6

Thiolation of protein-bound carcinogenic aldehyde. An electrophilic acrolein-lysine adduct that covalently binds to thiols.

Furuhata A, Nakamura M, Osawa T, Uchida K. Furuhata A, et al. Among authors: uchida k. J Biol Chem. 2002 Aug 2;277(31):27919-26. doi: 10.1074/jbc.M202794200. Epub 2002 May 24. J Biol Chem. 2002. PMID: 12032148 Free article.

Acrolein, a representative carcinogenic aldehyde that could be ubiquitously generated in biological systems under oxidative stress, shows facile reactivity with the epsilon-amino group of lysine to form N(epsilon)-(3-formyl-3,4-dehydropiperidino)lysine (FDP-lysine) as the major p …

Acrolein, a representative carcinogenic aldehyde that could be ubiquitously generated in biological systems under oxidative stress, shows fa …

7

15-Deoxy-Delta(12,14)-prostaglandin J(2): the endogenous electrophile that induces neuronal apoptosis.

Kondo M, Shibata T, Kumagai T, Osawa T, Shibata N, Kobayashi M, Sasaki S, Iwata M, Noguchi N, Uchida K. Kondo M, et al. Among authors: uchida k. Proc Natl Acad Sci U S A. 2002 May 28;99(11):7367-72. doi: 10.1073/pnas.112212599. Proc Natl Acad Sci U S A. 2002. PMID: 12032289 Free PMC article.

8

Selective formation of certain advanced glycation end products in spinal cord astrocytes of humans and mice with superoxide dismutase-1 mutation.

Shibata N, Hirano A, Hedley-Whyte ET, Dal Canto MC, Nagai R, Uchida K, Horiuchi S, Kawaguchi M, Yamamoto T, Kobayashi M. Shibata N, et al. Among authors: uchida k. Acta Neuropathol. 2002 Aug;104(2):171-8. doi: 10.1007/s00401-002-0537-5. Epub 2002 Apr 18. Acta Neuropathol. 2002. PMID: 12111360

9

Structural basis of protein-bound endogenous aldehydes. Chemical and immunochemical characterizations of configurational isomers of a 4-hydroxy-2-nonenal-histidine adduct.

Hashimoto M, Sibata T, Wasada H, Toyokuni S, Uchida K. Hashimoto M, et al. Among authors: uchida k. J Biol Chem. 2003 Feb 14;278(7):5044-51. doi: 10.1074/jbc.M210129200. Epub 2002 Dec 6. J Biol Chem. 2003. PMID: 12473681 Free article.

10

Molecular biological approaches to neurological disorders including knockout and transgenic mouse models.

Shibata N, Oda H, Hirano A, Kato Y, Kawaguchi M, Dal Canto MC, Uchida K, Sawada T, Kobayashi M. Shibata N, et al. Among authors: uchida k. Neuropathology. 2002 Dec;22(4):337-49. doi: 10.1046/j.1440-1789.2002.00449.x. Neuropathology. 2002. PMID: 12564775 Review.

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