Smith NJ - Search Results

1

Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator.

Smith NJ, Ward RJ, Stoddart LA, Hudson BD, Kostenis E, Ulven T, Morris JC, Tränkle C, Tikhonova IG, Adams DR, Milligan G. Smith NJ, et al. Mol Pharmacol. 2011 Jul;80(1):163-73. doi: 10.1124/mol.110.070789. Epub 2011 Apr 15. Mol Pharmacol. 2011. PMID: 21498659 Free PMC article.

2

Allosteric modulation of heterodimeric G-protein-coupled receptors.

Milligan G, Smith NJ. Milligan G, et al. Among authors: smith nj. Trends Pharmacol Sci. 2007 Dec;28(12):615-20. doi: 10.1016/j.tips.2007.11.001. Epub 2007 Nov 19. Trends Pharmacol Sci. 2007. PMID: 18022255 Review.

3

Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids.

Stoddart LA, Smith NJ, Jenkins L, Brown AJ, Milligan G. Stoddart LA, et al. Among authors: smith nj. J Biol Chem. 2008 Nov 21;283(47):32913-24. doi: 10.1074/jbc.M805601200. Epub 2008 Sep 18. J Biol Chem. 2008. PMID: 18801738 Free article.

4

International Union of Pharmacology. LXXI. Free fatty acid receptors FFA1, -2, and -3: pharmacology and pathophysiological functions.

Stoddart LA, Smith NJ, Milligan G. Stoddart LA, et al. Among authors: smith nj. Pharmacol Rev. 2008 Dec;60(4):405-17. doi: 10.1124/pr.108.00802. Epub 2008 Dec 1. Pharmacol Rev. 2008. PMID: 19047536 Review.

5

The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1.

Smith NJ, Stoddart LA, Devine NM, Jenkins L, Milligan G. Smith NJ, et al. J Biol Chem. 2009 Jun 26;284(26):17527-39. doi: 10.1074/jbc.M109.012849. Epub 2009 Apr 27. J Biol Chem. 2009. PMID: 19398560 Free PMC article.

6

Agonism and allosterism: the pharmacology of the free fatty acid receptors FFA2 and FFA3.

Milligan G, Stoddart LA, Smith NJ. Milligan G, et al. Among authors: smith nj. Br J Pharmacol. 2009 Sep;158(1):146-53. doi: 10.1111/j.1476-5381.2009.00421.x. Br J Pharmacol. 2009. PMID: 19719777 Free PMC article. Review.

7

When simple agonism is not enough: emerging modalities of GPCR ligands.

Smith NJ, Bennett KA, Milligan G. Smith NJ, et al. Mol Cell Endocrinol. 2011 Jan 15;331(2):241-7. doi: 10.1016/j.mce.2010.07.009. Epub 2010 Jul 21. Mol Cell Endocrinol. 2011. PMID: 20654693 Review.

8

Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements.

Schröder R, Janssen N, Schmidt J, Kebig A, Merten N, Hennen S, Müller A, Blättermann S, Mohr-Andrä M, Zahn S, Wenzel J, Smith NJ, Gomeza J, Drewke C, Milligan G, Mohr K, Kostenis E. Schröder R, et al. Among authors: smith nj. Nat Biotechnol. 2010 Sep;28(9):943-9. doi: 10.1038/nbt.1671. Epub 2010 Aug 15. Nat Biotechnol. 2010. PMID: 20711173 Free article.

9

Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13.

Jenkins L, Brea J, Smith NJ, Hudson BD, Reilly G, Bryant NJ, Castro M, Loza MI, Milligan G. Jenkins L, et al. Among authors: smith nj. Biochem J. 2010 Dec 15;432(3):451-9. doi: 10.1042/BJ20101287. Biochem J. 2010. PMID: 20919992

10

Allostery at G protein-coupled receptor homo- and heteromers: uncharted pharmacological landscapes.

Smith NJ, Milligan G. Smith NJ, et al. Pharmacol Rev. 2010 Dec;62(4):701-25. doi: 10.1124/pr.110.002667. Pharmacol Rev. 2010. PMID: 21079041 Free PMC article. Review.

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