Gay SC - Search Results

1

Structural analysis of mammalian cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene: insight into partial enzymatic activity.

Gay SC, Zhang H, Wilderman PR, Roberts AG, Liu T, Li S, Lin HL, Zhang Q, Woods VL Jr, Stout CD, Hollenberg PF, Halpert JR. Gay SC, et al. Biochemistry. 2011 Jun 7;50(22):4903-11. doi: 10.1021/bi200482g. Epub 2011 May 13. Biochemistry. 2011. PMID: 21510666 Free PMC article.

2

Crystal structures of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1H-imidazole: ligand-induced structural response through alpha-helical repositioning.

Gay SC, Sun L, Maekawa K, Halpert JR, Stout CD. Gay SC, et al. Biochemistry. 2009 Jun 9;48(22):4762-71. doi: 10.1021/bi9003765. Biochemistry. 2009. PMID: 19397311 Free PMC article.

3

Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution.

Gay SC, Shah MB, Talakad JC, Maekawa K, Roberts AG, Wilderman PR, Sun L, Yang JY, Huelga SC, Hong WX, Zhang Q, Stout CD, Halpert JR. Gay SC, et al. Mol Pharmacol. 2010 Apr;77(4):529-38. doi: 10.1124/mol.109.062570. Epub 2010 Jan 8. Mol Pharmacol. 2010. PMID: 20061448 Free PMC article.

4

Structures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrel.

Gay SC, Roberts AG, Maekawa K, Talakad JC, Hong WX, Zhang Q, Stout CD, Halpert JR. Gay SC, et al. Biochemistry. 2010 Oct 12;49(40):8709-20. doi: 10.1021/bi100914z. Epub 2010 Sep 15. Biochemistry. 2010. PMID: 20815363 Free PMC article.

5

Structural features of cytochromes P450 and ligands that affect drug metabolism as revealed by X-ray crystallography and NMR.

Gay SC, Roberts AG, Halpert JR. Gay SC, et al. Future Med Chem. 2010 Sep;2(9):1451-68. doi: 10.4155/fmc.10.229. Future Med Chem. 2010. PMID: 21103389 Free PMC article. Review.

6

Investigation by site-directed mutagenesis of the role of cytochrome P450 2B4 non-active-site residues in protein-ligand interactions based on crystal structures of the ligand-bound enzyme.

Wilderman PR, Gay SC, Jang HH, Zhang Q, Stout CD, Halpert JR. Wilderman PR, et al. Among authors: gay sc. FEBS J. 2012 May;279(9):1607-20. doi: 10.1111/j.1742-4658.2011.08411.x. Epub 2011 Nov 25. FEBS J. 2012. PMID: 22051155 Free PMC article.

7

Potent mechanism-based inactivation of cytochrome P450 2B4 by 9-ethynylphenanthrene: implications for allosteric modulation of cytochrome P450 catalysis.

Zhang H, Gay SC, Shah M, Foroozesh M, Liu J, Osawa Y, Zhang Q, Stout CD, Halpert JR, Hollenberg PF. Zhang H, et al. Among authors: gay sc. Biochemistry. 2013 Jan 15;52(2):355-64. doi: 10.1021/bi301567z. Epub 2013 Jan 4. Biochemistry. 2013. PMID: 23276288 Free PMC article.

8

Kinetic properties of ATP sulfurylase and APS kinase from Thiobacillus denitrificans.

Gay SC, Fribourgh JL, Donohoue PD, Segel IH, Fisher AJ. Gay SC, et al. Arch Biochem Biophys. 2009 Sep;489(1-2):110-7. doi: 10.1016/j.abb.2009.07.026. Epub 2009 Aug 5. Arch Biochem Biophys. 2009. PMID: 19664586

9

Structure of the two-domain hexameric APS kinase from Thiobacillus denitrificans: structural basis for the absence of ATP sulfurylase activity.

Gay SC, Segel IH, Fisher AJ. Gay SC, et al. Acta Crystallogr D Biol Crystallogr. 2009 Oct;65(Pt 10):1021-31. doi: 10.1107/S0907444909026547. Epub 2009 Sep 16. Acta Crystallogr D Biol Crystallogr. 2009. PMID: 19770499 Free PMC article.

10

Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3-Oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl Moiety.

Ikeda S, Sugiyama H, Tokuhara H, Murakami M, Nakamura M, Oguro Y, Aida J, Morishita N, Sogabe S, Dougan DR, Gay SC, Qin L, Arimura N, Takahashi Y, Sasaki M, Kamada Y, Aoyama K, Kimoto K, Kamata M. Ikeda S, et al. Among authors: gay sc. J Med Chem. 2021 Aug 12;64(15):11014-11044. doi: 10.1021/acs.jmedchem.1c00432. Epub 2021 Jul 30. J Med Chem. 2021. PMID: 34328319

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