Prat A - Search Results

1

PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke.

Rousselet E, Marcinkiewicz J, Kriz J, Zhou A, Hatten ME, Prat A, Seidah NG. Rousselet E, et al. Among authors: prat a. J Lipid Res. 2011 Jul;52(7):1383-91. doi: 10.1194/jlr.M014118. Epub 2011 Apr 25. J Lipid Res. 2011. PMID: 21518694 Free PMC article.

2

The Kex2p proregion is essential for the biosynthesis of an active enzyme and requires a C-terminal basic residue for its function.

Lesage G, Prat A, Lacombe J, Thomas DY, Seidah NG, Boileau G. Lesage G, et al. Among authors: prat a. Mol Biol Cell. 2000 Jun;11(6):1947-57. doi: 10.1091/mbc.11.6.1947. Mol Biol Cell. 2000. PMID: 10848621 Free PMC article.

3

Inhibition of proprotein convertases is associated with loss of growth and tumorigenicity of HT-29 human colon carcinoma cells: importance of insulin-like growth factor-1 (IGF-1) receptor processing in IGF-1-mediated functions.

Khatib AM, Siegfried G, Prat A, Luis J, Chrétien M, Metrakos P, Seidah NG. Khatib AM, et al. Among authors: prat a. J Biol Chem. 2001 Aug 17;276(33):30686-93. doi: 10.1074/jbc.M101725200. Epub 2001 Jun 11. J Biol Chem. 2001. PMID: 11402025 Free article.

4

The metalloendopeptidase nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF).

Hospital V, Nishi E, Klagsbrun M, Cohen P, Seidah NG, Prat A. Hospital V, et al. Among authors: prat a. Biochem J. 2002 Oct 1;367(Pt 1):229-38. doi: 10.1042/BJ20020822. Biochem J. 2002. PMID: 12095415 Free PMC article.

5

Precursor convertases in the secretory pathway, cytosol and extracellular milieu.

Seidah NG, Prat A. Seidah NG, et al. Among authors: prat a. Essays Biochem. 2002;38:79-94. doi: 10.1042/bse0380079. Essays Biochem. 2002. PMID: 12463163 Review.

6

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation.

Seidah NG, Benjannet S, Wickham L, Marcinkiewicz J, Jasmin SB, Stifani S, Basak A, Prat A, Chretien M. Seidah NG, et al. Among authors: prat a. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):928-33. doi: 10.1073/pnas.0335507100. Epub 2003 Jan 27. Proc Natl Acad Sci U S A. 2003. PMID: 12552133 Free PMC article.

7

Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia.

Dubuc G, Chamberland A, Wassef H, Davignon J, Seidah NG, Bernier L, Prat A. Dubuc G, et al. Among authors: prat a. Arterioscler Thromb Vasc Biol. 2004 Aug;24(8):1454-9. doi: 10.1161/01.ATV.0000134621.14315.43. Epub 2004 Jun 3. Arterioscler Thromb Vasc Biol. 2004. PMID: 15178557

8

NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol.

Benjannet S, Rhainds D, Essalmani R, Mayne J, Wickham L, Jin W, Asselin MC, Hamelin J, Varret M, Allard D, Trillard M, Abifadel M, Tebon A, Attie AD, Rader DJ, Boileau C, Brissette L, Chrétien M, Prat A, Seidah NG. Benjannet S, et al. Among authors: prat a. J Biol Chem. 2004 Nov 19;279(47):48865-75. doi: 10.1074/jbc.M409699200. Epub 2004 Sep 9. J Biol Chem. 2004. PMID: 15358785 Free article.

9

Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse.

Essalmani R, Hamelin J, Marcinkiewicz J, Chamberland A, Mbikay M, Chrétien M, Seidah NG, Prat A. Essalmani R, et al. Among authors: prat a. Mol Cell Biol. 2006 Jan;26(1):354-61. doi: 10.1128/MCB.26.1.354-361.2006. Mol Cell Biol. 2006. PMID: 16354705 Free PMC article.

10

Implication of the proprotein convertase NARC-1/PCSK9 in the development of the nervous system.

Poirier S, Prat A, Marcinkiewicz E, Paquin J, Chitramuthu BP, Baranowski D, Cadieux B, Bennett HP, Seidah NG. Poirier S, et al. Among authors: prat a. J Neurochem. 2006 Aug;98(3):838-50. doi: 10.1111/j.1471-4159.2006.03928.x. J Neurochem. 2006. PMID: 16893422 Free article.

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