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Down-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferation.
Orlovsky K, Kalinkovich A, Rozovskaia T, Shezen E, Itkin T, Alder H, Ozer HG, Carramusa L, Avigdor A, Volinia S, Buchberg A, Mazo A, Kollet O, Largman C, Croce CM, Nakamura T, Lapidot T, Canaani E. Orlovsky K, et al. Among authors: largman c. Proc Natl Acad Sci U S A. 2011 May 10;108(19):7956-61. doi: 10.1073/pnas.1103154108. Epub 2011 Apr 25. Proc Natl Acad Sci U S A. 2011. PMID: 21518888 Free PMC article.
MicroRNA-126 regulates HOXA9 by binding to the homeobox.
Shen WF, Hu YL, Uttarwar L, Passegue E, Largman C. Shen WF, et al. Among authors: largman c. Mol Cell Biol. 2008 Jul;28(14):4609-19. doi: 10.1128/MCB.01652-07. Epub 2008 May 12. Mol Cell Biol. 2008. PMID: 18474618 Free PMC article.
HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivo.
Fischbach NA, Rozenfeld S, Shen W, Fong S, Chrobak D, Ginzinger D, Kogan SC, Radhakrishnan A, Le Beau MM, Largman C, Lawrence HJ. Fischbach NA, et al. Among authors: largman c. Blood. 2005 Feb 15;105(4):1456-66. doi: 10.1182/blood-2004-04-1583. Epub 2004 Nov 2. Blood. 2005. PMID: 15522959 Free article.
112 results