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Phase I study of U3-1287, a fully human anti-HER3 monoclonal antibody, in patients with advanced solid tumors.
LoRusso P, Jänne PA, Oliveira M, Rizvi N, Malburg L, Keedy V, Yee L, Copigneaux C, Hettmann T, Wu CY, Ang A, Halim AB, Beckman RA, Beaupre D, Berlin J. LoRusso P, et al. Among authors: hettmann t. Clin Cancer Res. 2013 Jun 1;19(11):3078-87. doi: 10.1158/1078-0432.CCR-12-3051. Epub 2013 Apr 16. Clin Cancer Res. 2013. PMID: 23591447 Clinical Trial.
Focused ultrasound with anti-pGlu3 Aβ enhances efficacy in Alzheimer's disease-like mice via recruitment of peripheral immune cells.
Sun T, Shi Q, Zhang Y, Power C, Hoesch C, Antonelli S, Schroeder MK, Caldarone BJ, Taudte N, Schenk M, Hettmann T, Schilling S, McDannold NJ, Lemere CA. Sun T, et al. Among authors: hettmann t. J Control Release. 2021 Aug 10;336:443-456. doi: 10.1016/j.jconrel.2021.06.037. Epub 2021 Jun 26. J Control Release. 2021. PMID: 34186148 Free PMC article.
Effector function of anti-pyroglutamate-3 Aβ antibodies affects cognitive benefit, glial activation and amyloid clearance in Alzheimer's-like mice.
Crehan H, Liu B, Kleinschmidt M, Rahfeld JU, Le KX, Caldarone BJ, Frost JL, Hettmann T, Hutter-Paier B, O'Nuallain B, Park MA, DiCarli MF, Lues I, Schilling S, Lemere CA. Crehan H, et al. Among authors: hettmann t. Alzheimers Res Ther. 2020 Jan 13;12(1):12. doi: 10.1186/s13195-019-0579-8. Alzheimers Res Ther. 2020. PMID: 31931873 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 34971185
Clinical Translation and Validation of a Predictive Biomarker for Patritumab, an Anti-human Epidermal Growth Factor Receptor 3 (HER3) Monoclonal Antibody, in Patients With Advanced Non-small Cell Lung Cancer.
Mendell J, Freeman DJ, Feng W, Hettmann T, Schneider M, Blum S, Ruhe J, Bange J, Nakamaru K, Chen S, Tsuchihashi Z, von Pawel J, Copigneaux C, Beckman RA. Mendell J, et al. Among authors: hettmann t. EBioMedicine. 2015 Feb 12;2(3):264-71. doi: 10.1016/j.ebiom.2015.02.005. eCollection 2015 Mar. EBioMedicine. 2015. PMID: 26137564 Free PMC article. Clinical Trial.
Structural basis of IL-23 antagonism by an Alphabody protein scaffold.
Desmet J, Verstraete K, Bloch Y, Lorent E, Wen Y, Devreese B, Vandenbroucke K, Loverix S, Hettmann T, Deroo S, Somers K, Henderikx P, Lasters I, Savvides SN. Desmet J, et al. Among authors: hettmann t. Nat Commun. 2014 Oct 30;5:5237. doi: 10.1038/ncomms6237. Nat Commun. 2014. PMID: 25354530 Free PMC article.
24 results