Borthwick AD - Search Results

1

Fluoro carbocyclic nucleosides: synthesis and antiviral activity of 2'- and 6'-fluoro carbocyclic pyrimidine nucleosides including carbocyclic 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-methyluracil and carbocyclic 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodouracil.

Borthwick AD, Evans DN, Kirk BE, Biggadike K, Exall AM, Youds P, Roberts SM, Knight DJ, Coates JA. Borthwick AD, et al. J Med Chem. 1990 Jan;33(1):179-86. doi: 10.1021/jm00163a030. J Med Chem. 1990. PMID: 2153201

2

Fluorocarbocyclic nucleosides: synthesis and antiviral activity of 2'- and 6'-fluorocarbocyclic 2'-deoxy guanosines.

Borthwick AD, Kirk BE, Biggadike K, Exall AM, Butt S, Roberts SM, Knight DJ, Coates JA, Ryan DM. Borthwick AD, et al. J Med Chem. 1991 Mar;34(3):907-14. doi: 10.1021/jm00107a006. J Med Chem. 1991. PMID: 1848298

3

Design and synthesis of pyrrolidine-5,5-trans-lactams (5-oxo-hexahydro-pyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 1. The alpha-methyl-trans-lactam template.

Borthwick AD, Angier SJ, Crame AJ, Exall AM, Haley TM, Hart GJ, Mason AM, Pennell AM, Weingarten GG. Borthwick AD, et al. J Med Chem. 2000 Nov 16;43(23):4452-64. doi: 10.1021/jm000078q. J Med Chem. 2000. PMID: 11087570

4

Design and synthesis of pyrrolidine-5,5-trans-lactams (5-oxohexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 2. Potency and chirality.

Borthwick AD, Crame AJ, Ertl PF, Exall AM, Haley TM, Hart GJ, Mason AM, Pennell AM, Singh OM, Weingarten GG, Woolven JM. Borthwick AD, et al. J Med Chem. 2002 Jan 3;45(1):1-18. doi: 10.1021/jm0102203. J Med Chem. 2002. PMID: 11754575

5

Design and synthesis of pyrrolidine-5,5'-trans-lactams (5-oxo-hexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 4. Antiviral activity and plasma stability.

Borthwick AD, Davies DE, Ertl PF, Exall AM, Haley TM, Hart GJ, Jackson DL, Parry NR, Patikis A, Trivedi N, Weingarten GG, Woolven JM. Borthwick AD, et al. J Med Chem. 2003 Oct 9;46(21):4428-49. doi: 10.1021/jm030810w. J Med Chem. 2003. PMID: 14521407

6

2,5-diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists. 2. Synthesis, chirality, and pharmacokinetics.

Borthwick AD, Davies DE, Exall AM, Livermore DG, Sollis SL, Nerozzi F, Allen MJ, Perren M, Shabbir SS, Woollard PM, Wyatt PG. Borthwick AD, et al. J Med Chem. 2005 Nov 3;48(22):6956-69. doi: 10.1021/jm050557v. J Med Chem. 2005. PMID: 16250654

7

Pyrrolidine-5,5-trans-lactams as novel mechanism-based inhibitors of human cytomegalovirus protease. Part 3: potency and plasma stability.

Borthwick AD, Exall AM, Haley TM, Jackson DL, Mason AM, Weingarten GG. Borthwick AD, et al. Bioorg Med Chem Lett. 2002 Jul 8;12(13):1719-22. doi: 10.1016/s0960-894x(02)00294-9. Bioorg Med Chem Lett. 2002. PMID: 12067545

8

2,5-diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists. 3. Synthesis, pharmacokinetics, and in vivo potency.

Borthwick AD, Davies DE, Exall AM, Hatley RJ, Hughes JA, Irving WR, Livermore DG, Sollis SL, Nerozzi F, Valko KL, Allen MJ, Perren M, Shabbir SS, Woollard PM, Price MA. Borthwick AD, et al. J Med Chem. 2006 Jul 13;49(14):4159-70. doi: 10.1021/jm060073e. J Med Chem. 2006. PMID: 16821776

9

2,5-Diketopiperazines as potent and selective oxytocin antagonists 1: Identification, stereochemistry and initial SAR.

Wyatt PG, Allen MJ, Borthwick AD, Davies DE, Exall AM, Hatley RJ, Irving WR, Livermore DG, Miller ND, Nerozzi F, Sollis SL, Szardenings AK. Wyatt PG, et al. Among authors: borthwick ad. Bioorg Med Chem Lett. 2005 May 16;15(10):2579-82. doi: 10.1016/j.bmcl.2005.03.045. Bioorg Med Chem Lett. 2005. PMID: 15863320

10

Pyridyl-2,5-diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists: synthesis, pharmacokinetics, and in vivo potency.

Borthwick AD, Liddle J, Davies DE, Exall AM, Hamlett C, Hickey DM, Mason AM, Smith IE, Nerozzi F, Peace S, Pollard D, Sollis SL, Allen MJ, Woollard PM, Pullen MA, Westfall TD, Stanislaus DJ. Borthwick AD, et al. J Med Chem. 2012 Jan 26;55(2):783-96. doi: 10.1021/jm201287w. Epub 2012 Jan 12. J Med Chem. 2012. PMID: 22239250

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