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Site-directed mutagenesis of aldehyde dehydrogenase-2 suggests three distinct pathways of nitroglycerin biotransformation.
Mol Pharmacol. 2011 Aug;80(2):258-66. doi: 10.1124/mol.111.071704. Epub 2011 May 2.
Mol Pharmacol. 2011.
PMID: 21536753
Bioactivation of pentaerythrityl tetranitrate by mitochondrial aldehyde dehydrogenase.
Griesberger M, Kollau A, Wölkart G, Wenzl MV, Beretta M, Russwurm M, Koesling D, Schmidt K, Gorren AC, Mayer B.
Griesberger M, et al.
Mol Pharmacol. 2011 Mar;79(3):541-8. doi: 10.1124/mol.110.069138. Epub 2010 Dec 14.
Mol Pharmacol. 2011.
PMID: 21156756
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Vascular bioactivation of nitroglycerin is catalyzed by cytosolic aldehyde dehydrogenase-2.
Beretta M, Wölkart G, Schernthaner M, Griesberger M, Neubauer R, Schmidt K, Sacherer M, Heinzel FR, Kohlwein SD, Mayer B.
Beretta M, et al. Among authors: griesberger m.
Circ Res. 2012 Feb 3;110(3):385-93. doi: 10.1161/CIRCRESAHA.111.245837. Epub 2011 Dec 29.
Circ Res. 2012.
PMID: 22207712
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