Lee SS - Search Results

1

Effects of the anti-sepsis drug, (S)-1-(α-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (CKD-712), on mortality, inflammation, and organ injuries in rodent sepsis models.

Park JH, Hwang IC, Ha N, Lee S, Kim JM, Lee SS, Yu H, Lim IT, You JA, Kim DH. Park JH, et al. Among authors: lee ss, lee s. Arch Pharm Res. 2011 Mar;34(3):485-94. doi: 10.1007/s12272-011-0318-6. Epub 2011 May 6. Arch Pharm Res. 2011. PMID: 21547682

2

CKD712, (S)-1-(α-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, inhibits the lipopolysaccharide-stimulated secretion of HMGB1 by inhibiting PI3K and classical protein kinase C.

Oh YJ, Youn JH, Min HJ, Kim DH, Lee SS, Choi IH, Shin JS. Oh YJ, et al. Among authors: lee ss. Int Immunopharmacol. 2011 Sep;11(9):1160-5. doi: 10.1016/j.intimp.2011.03.013. Epub 2011 Mar 30. Int Immunopharmacol. 2011. PMID: 21457762

3

CKD-712, (S)-1-(α-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, Inhibits the NF-κB Activation and Augments Akt Activation during TLR4 Signaling.

Lee J, Yang EJ, Shin JS, Kim DH, Lee SS, Choi IH. Lee J, et al. Among authors: lee ss. Immune Netw. 2011 Dec;11(6):420-3. doi: 10.4110/in.2011.11.6.420. Epub 2011 Dec 31. Immune Netw. 2011. PMID: 22346785 Free PMC article.

4

Discovery of potent, selective, and orally bioavailable PDE5 inhibitor: Methyl-4-(3-chloro-4-methoxybenzylamino)-8-(2-hydroxyethyl)-7-methoxyquinazolin-6-ylmethylcarbamate (CKD 533).

Choi H, Lee J, Kim YH, Im DS, Hwang IC, Kim SJ, Moon SK, Lee HW, Lee SS, Ahn SK, Kim SW, Choi NS, Lee KJ. Choi H, et al. Among authors: lee j, lee hw, lee kj, lee ss. Bioorg Med Chem Lett. 2010 Jan 1;20(1):383-6. doi: 10.1016/j.bmcl.2009.10.071. Epub 2009 Oct 21. Bioorg Med Chem Lett. 2010. PMID: 19906530

5

Discovery of a potent tubulin polymerization inhibitor: synthesis and evaluation of water-soluble prodrugs of benzophenone analog.

Lee J, Bae S, Lee SH, Choi H, Kim YH, Kim SJ, Park GT, Moon SK, Kim DH, Lee S, Ahn SK, Choi NS, Lee KJ. Lee J, et al. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6327-30. doi: 10.1016/j.bmcl.2010.05.060. Epub 2010 May 20. Bioorg Med Chem Lett. 2010. PMID: 20850313

6

Quinazolines as potent and highly selective PDE5 inhibitors as potential therapeutics for male erectile dysfunction.

Kim YH, Choi H, Lee J, Hwang IC, Moon SK, Kim SJ, Lee HW, Im DS, Lee SS, Ahn SK, Kim SW, Han CK, Yoon JH, Lee KJ, Choi NS. Kim YH, et al. Among authors: lee j, lee hw, lee kj, lee ss. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6279-82. doi: 10.1016/j.bmcl.2008.09.108. Epub 2008 Oct 11. Bioorg Med Chem Lett. 2008. PMID: 18976905

7

Identification of CKD-516: a potent tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors.

Lee J, Kim SJ, Choi H, Kim YH, Lim IT, Yang HM, Lee CS, Kang HR, Ahn SK, Moon SK, Kim DH, Lee S, Choi NS, Lee KJ. Lee J, et al. J Med Chem. 2010 Sep 9;53(17):6337-54. doi: 10.1021/jm1002414. J Med Chem. 2010. PMID: 20690624

8

(S)-tetrahydroisoquinoline alkaloid inhibits LPS-induced arachidonic acid release through downregulation of cPLA2 expression.

Choi JM, Choi YH, Kim SK, Ahn KH, Won JH, Lim JH, Jang YJ, Lee S, Kim DH, Kim DK. Choi JM, et al. Mol Cells. 2013 Nov;36(5):400-9. doi: 10.1007/s10059-013-0078-x. Epub 2013 Nov 14. Mol Cells. 2013. PMID: 24293010 Free PMC article.

9

HO-1 and JAK-2/STAT-1 signals are involved in preferential inhibition of iNOS over COX-2 gene expression by newly synthesized tetrahydroisoquinoline alkaloid, CKD712, in cells activated with lipopolysacchride.

Tsoyi K, Kim HJ, Shin JS, Kim DH, Cho HJ, Lee SS, Ahn SK, Yun-Choi HS, Lee JH, Seo HG, Chang KC. Tsoyi K, et al. Among authors: lee jh, lee ss. Cell Signal. 2008 Oct;20(10):1839-47. doi: 10.1016/j.cellsig.2008.06.012. Epub 2008 Jun 27. Cell Signal. 2008. PMID: 18634870

10

Absorption, distribution, metabolism, and excretion of CKD-732, a novel antiangiogenic fumagillin derivative, in rats, mice, and dogs.

Lee HS, Choi WK, Son HJ, Lee SS, Kim JK, Ahn SK, Hong CI, Min HK, Kim M, Myung SW. Lee HS, et al. Among authors: lee ss. Arch Pharm Res. 2004 Feb;27(2):265-72. doi: 10.1007/BF02980116. Arch Pharm Res. 2004. PMID: 15029870

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