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Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535.
Duplantier AJ, Dombroski MA, Subramanyam C, Beaulieu AM, Chang SP, Gabel CA, Jordan C, Kalgutkar AS, Kraus KG, Labasi JM, Mussari C, Perregaux DG, Shepard R, Taylor TJ, Trevena KA, Whitney-Pickett C, Yoon K. Duplantier AJ, et al. Among authors: jordan c. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3708-11. doi: 10.1016/j.bmcl.2011.04.077. Epub 2011 Apr 24. Bioorg Med Chem Lett. 2011. PMID: 21565499
Benzimidazolone p38 inhibitors.
Dombroski MA, Letavic MA, McClure KF, Barberia JT, Carty TJ, Cortina SR, Csiki C, Dipesa AJ, Elliott NC, Gabel CA, Jordan CK, Labasi JM, Martin WH, Peese KM, Stock IA, Svensson L, Sweeney FJ, Yu CH. Dombroski MA, et al. Among authors: jordan ck. Bioorg Med Chem Lett. 2004 Feb 23;14(4):919-23. doi: 10.1016/j.bmcl.2003.12.023. Bioorg Med Chem Lett. 2004. PMID: 15012994
Structure-activity relationships of triazolopyridine oxazole p38 inhibitors: identification of candidates for clinical development.
McClure KF, Letavic MA, Kalgutkar AS, Gabel CA, Audoly L, Barberia JT, Braganza JF, Carter D, Carty TJ, Cortina SR, Dombroski MA, Donahue KM, Elliott NC, Gibbons CP, Jordan CK, Kuperman AV, Labasi JM, Laliberte RE, McCoy JM, Naiman BM, Nelson KL, Nguyen HT, Peese KM, Sweeney FJ, Taylor TJ, Trebino CE, Abramov YA, Laird ER, Volberg WA, Zhou J, Bach J, Lombardo F. McClure KF, et al. Among authors: jordan ck. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4339-44. doi: 10.1016/j.bmcl.2006.05.056. Epub 2006 Jun 12. Bioorg Med Chem Lett. 2006. PMID: 16759861
Purine metabolites regulate leukemic cell sensitivity toward cytarabine.
Zhang X, Jia A, You J, Zhuang Z, Wang Y, Liu T, Du X, Huang L, Li P, Zhao TJ, Jordan CT, Chen L, Zhou JH, Ye H. Zhang X, et al. Among authors: jordan ct. Haematologica. 2025 Jan 9. doi: 10.3324/haematol.2024.286308. Online ahead of print. Haematologica. 2025. PMID: 39781620
The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication.
Baker PJ, Bohrer AC, Castro E, Amaral EP, Snow-Smith M, Torres-Juárez F, Gould ST, Queiroz ATL, Fukutani ER, Jordan CM, Khillan JS, Cho K, Barber DL, Andrade BB, Johnson RF, Hilligan KL, Mayer-Barber KD. Baker PJ, et al. Among authors: jordan cm. Sci Immunol. 2024 Dec 6;9(102):eadp7951. doi: 10.1126/sciimmunol.adp7951. Epub 2024 Dec 6. Sci Immunol. 2024. PMID: 39642242
International PCOS guideline clinical research priorities roadmap: a co-designed approach aligned with end-user priorities in a neglected women's health condition.
Teede HJ, Gibson M, Laven J, Dokras A, Moran LJ, Piltonin T, Costello M, Mousa A, Joham AE, Tay CT; International PCOS Network. Teede HJ, et al. EClinicalMedicine. 2024 Nov 15;78:102927. doi: 10.1016/j.eclinm.2024.102927. eCollection 2024 Dec. EClinicalMedicine. 2024. PMID: 39634033 Free PMC article.
Differences in HIV risk factors between South African adolescents and adult women and their association with sexually transmitted infections.
Mkhize P, Mehou-Loko C, Maphumulo N, Radzey N, Abrahams AG, Sibeko S, Harryparsad R, Manhanzva M, Meyer B, Radebe P, Liebenberg LJP, Ngcapu S, Ahmed N, Busakwe F, Mqaba N, Archary D, Sivro A, Samsunder N, Potloane D, Horsnell W, Jordan C, Abdool Karim Q, Bekker LG, Passmore JA, Jaspan H, Humphries H, Masson L. Mkhize P, et al. Among authors: jordan c. Sex Transm Infect. 2024 Dec 4:sextrans-2024-056260. doi: 10.1136/sextrans-2024-056260. Online ahead of print. Sex Transm Infect. 2024. PMID: 39632075 Free article.
1,287 results