Zhen X - Search Results

1

Identification of N-propylnoraporphin-11-yl 5-(1,2-dithiolan-3-yl)pentanoate as a new anti-Parkinson's agent possessing a dopamine D2 and serotonin 5-HT1A dual-agonist profile.

Zhang H, Ye N, Zhou S, Guo L, Zheng L, Liu Z, Gao B, Zhen X, Zhang A. Zhang H, et al. Among authors: zhen x. J Med Chem. 2011 Jul 14;54(13):4324-38. doi: 10.1021/jm200347t. Epub 2011 Jun 2. J Med Chem. 2011. PMID: 21591752

2

N-Propylnoraporphin-11-O-yl carboxylic esters as potent dopamine D(2) and serotonin 5-HT(1A) receptor dual ligands.

Liu Z, Chen X, Sun P, Yu L, Zhen X, Zhang A. Liu Z, et al. Among authors: zhen x. Bioorg Med Chem. 2008 Sep 15;16(18):8335-8. doi: 10.1016/j.bmc.2008.08.056. Epub 2008 Aug 28. Bioorg Med Chem. 2008. PMID: 18783955

3

Synthesis of dihydrofuroaporphine derivatives: identification of a potent and selective serotonin 5-HT 1A receptor agonist.

Liu Z, Zhang H, Ye N, Zhang J, Wu Q, Sun P, Li L, Zhen X, Zhang A. Liu Z, et al. Among authors: zhen x. J Med Chem. 2010 Feb 11;53(3):1319-28. doi: 10.1021/jm9015763. J Med Chem. 2010. PMID: 20041669

4

Further SAR study on 11-O-substituted aporphine analogues: identification of highly potent dopamine D3 receptor ligands.

Ye N, Wu Q, Zhu L, Zheng L, Gao B, Zhen X, Zhang A. Ye N, et al. Among authors: zhen x. Bioorg Med Chem. 2011 Mar 15;19(6):1999-2008. doi: 10.1016/j.bmc.2011.01.053. Epub 2011 Jan 31. Bioorg Med Chem. 2011. PMID: 21334902

5

Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile.

Sun H, Zhu L, Yang H, Qian W, Guo L, Zhou S, Gao B, Li Z, Zhou Y, Jiang H, Chen K, Zhen X, Liu H. Sun H, et al. Among authors: zhen x. Bioorg Med Chem. 2013 Feb 15;21(4):856-68. doi: 10.1016/j.bmc.2012.12.016. Epub 2012 Dec 21. Bioorg Med Chem. 2013. PMID: 23332346

6

(6aR)-11-amino-N-propyl-noraporphine, a new dopamine D2 and serotonin 5-HT1A dual agonist, elicits potent antiparkinsonian action and attenuates levodopa-induced dyskinesia in a 6-OHDA-lesioned rat model of Parkinson's disease.

Zhao R, Lu W, Fang X, Guo L, Yang Z, Ye N, Zhao J, Liu Z, Jia J, Zheng L, Zhao B, Zhang A, Zhen X. Zhao R, et al. Among authors: zhen x. Pharmacol Biochem Behav. 2014 Sep;124:204-10. doi: 10.1016/j.pbb.2014.06.011. Epub 2014 Jun 21. Pharmacol Biochem Behav. 2014. PMID: 24955866

7

Structural manipulation on the catecholic fragment of dopamine D(1) receptor agonist 1-phenyl-N-methyl-benzazepines.

Zhang J, Huang J, Song Z, Guo L, Cai W, Wang Y, Zhen X, Zhang A. Zhang J, et al. Among authors: zhen x. Eur J Med Chem. 2014 Oct 6;85:16-26. doi: 10.1016/j.ejmech.2014.07.059. Epub 2014 Jul 24. Eur J Med Chem. 2014. PMID: 25076379

8

Design, synthesis and evaluation of benzo[a]thieno[3,2-g]quinolizines as novel l-SPD derivatives possessing dopamine D1, D2 and serotonin 5-HT1A multiple action profiles.

Li Z, Huang J, Sun H, Zhou S, Guo L, Zhou Y, Zhen X, Liu H. Li Z, et al. Among authors: zhen x. Bioorg Med Chem. 2014 Nov 1;22(21):5838-46. doi: 10.1016/j.bmc.2014.09.024. Epub 2014 Sep 19. Bioorg Med Chem. 2014. PMID: 25308766

9

Sigma-2 receptor ligands: neurobiological effects.

Guo L, Zhen X. Guo L, et al. Among authors: zhen x. Curr Med Chem. 2015;22(8):989-1003. doi: 10.2174/0929867322666150114163607. Curr Med Chem. 2015. PMID: 25620095 Review.

10

Synthesis and pharmacological investigation of novel 2-aminothiazole-privileged aporphines.

Liu Z, Chen X, Yu L, Zhen X, Zhang A. Liu Z, et al. Among authors: zhen x. Bioorg Med Chem. 2008 Jul 15;16(14):6675-81. doi: 10.1016/j.bmc.2008.05.077. Epub 2008 Jun 5. Bioorg Med Chem. 2008. PMID: 18562201

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