Erion MD - Search Results

1

Antiviral efficacy upon administration of a HepDirect prodrug of 2'-C-methylcytidine to hepatitis C virus-infected chimpanzees.

Carroll SS, Koeplinger K, Vavrek M, Zhang NR, Handt L, MacCoss M, Olsen DB, Reddy KR, Sun Z, van Poelje PD, Fujitaki JM, Boyer SH, Linemeyer DL, Hecker SJ, Erion MD. Carroll SS, et al. Among authors: erion md. Antimicrob Agents Chemother. 2011 Aug;55(8):3854-60. doi: 10.1128/AAC.01152-10. Epub 2011 May 31. Antimicrob Agents Chemother. 2011. PMID: 21628542 Free PMC article.

2

Liver targeting of hepatitis-B antiviral lamivudine using the HepDirect prodrug technology.

Reddy KR, Colby TJ, Fujitaki JM, van Poelje PD, Erion MD. Reddy KR, et al. Among authors: erion md. Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):375-81. doi: 10.1081/ncn-200059781. Nucleosides Nucleotides Nucleic Acids. 2005. PMID: 16247954

3

Liver-targeted prodrugs of 2'-C-methyladenosine for therapy of hepatitis C virus infection.

Hecker SJ, Reddy KR, van Poelje PD, Sun Z, Huang W, Varkhedkar V, Reddy MV, Fujitaki JM, Olsen DB, Koeplinger KA, Boyer SH, Linemeyer DL, MacCoss M, Erion MD. Hecker SJ, et al. Among authors: erion md. J Med Chem. 2007 Aug 9;50(16):3891-6. doi: 10.1021/jm0701021. Epub 2007 Jul 18. J Med Chem. 2007. PMID: 17636948

4

Pradefovir: a prodrug that targets adefovir to the liver for the treatment of hepatitis B.

Reddy KR, Matelich MC, Ugarkar BG, Gómez-Galeno JE, DaRe J, Ollis K, Sun Z, Craigo W, Colby TJ, Fujitaki JM, Boyer SH, van Poelje PD, Erion MD. Reddy KR, et al. Among authors: erion md. J Med Chem. 2008 Feb 14;51(3):666-76. doi: 10.1021/jm7012216. Epub 2008 Jan 4. J Med Chem. 2008. PMID: 18173234

5

Preclinical pharmacokinetics of a HepDirect prodrug of a novel phosphonate-containing thyroid hormone receptor agonist.

Fujitaki JM, Cable EE, Ito BR, Zhang BH, Hou J, Yang C, Bullough DA, Ferrero JL, van Poelje PD, Linemeyer DL, Erion MD. Fujitaki JM, et al. Among authors: erion md. Drug Metab Dispos. 2008 Nov;36(11):2393-403. doi: 10.1124/dmd.108.021642. Epub 2008 Aug 14. Drug Metab Dispos. 2008. PMID: 18703645

6

Delivery of high levels of anti-proliferative nucleoside triphosphates to CYP3A-expressing cells as a potential treatment for hepatocellular carcinoma.

MacKenna DA, Montag A, Boyer SH, Linemeyer DL, Erion MD. MacKenna DA, et al. Among authors: erion md. Cancer Chemother Pharmacol. 2009 Oct;64(5):981-91. doi: 10.1007/s00280-009-0953-5. Epub 2009 Mar 13. Cancer Chemother Pharmacol. 2009. PMID: 19283354

7

Liver-targeted drug delivery using HepDirect prodrugs.

Erion MD, van Poelje PD, Mackenna DA, Colby TJ, Montag AC, Fujitaki JM, Linemeyer DL, Bullough DA. Erion MD, et al. J Pharmacol Exp Ther. 2005 Feb;312(2):554-60. doi: 10.1124/jpet.104.075903. Epub 2004 Aug 31. J Pharmacol Exp Ther. 2005. PMID: 15340017

8

Synthesis and characterization of a novel liver-targeted prodrug of cytosine-1-beta-D-arabinofuranoside monophosphate for the treatment of hepatocellular carcinoma.

Boyer SH, Sun Z, Jiang H, Esterbrook J, Gómez-Galeno JE, Craigo W, Reddy KR, Ugarkar BG, MacKenna DA, Erion MD. Boyer SH, et al. Among authors: erion md. J Med Chem. 2006 Dec 28;49(26):7711-20. doi: 10.1021/jm0607449. J Med Chem. 2006. PMID: 17181153

9

Fructose-1, 6-bisphosphatase inhibitors for reducing excessive endogenous glucose production in type 2 diabetes.

van Poelje PD, Potter SC, Erion MD. van Poelje PD, et al. Among authors: erion md. Handb Exp Pharmacol. 2011;(203):279-301. doi: 10.1007/978-3-642-17214-4_12. Handb Exp Pharmacol. 2011. PMID: 21484576 Review.

10

Design, synthesis, and characterization of a series of cytochrome P(450) 3A-activated prodrugs (HepDirect prodrugs) useful for targeting phosph(on)ate-based drugs to the liver.

Erion MD, Reddy KR, Boyer SH, Matelich MC, Gomez-Galeno J, Lemus RH, Ugarkar BG, Colby TJ, Schanzer J, Van Poelje PD. Erion MD, et al. J Am Chem Soc. 2004 Apr 28;126(16):5154-63. doi: 10.1021/ja031818y. J Am Chem Soc. 2004. PMID: 15099098

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