Talman V - Search Results

1

C1 Domain-targeted isophthalate derivatives induce cell elongation and cell cycle arrest in HeLa cells.

Talman V, Tuominen RK, Boije af Gennäs G, Yli-Kauhaluoma J, Ekokoski E. Talman V, et al. PLoS One. 2011;6(5):e20053. doi: 10.1371/journal.pone.0020053. Epub 2011 May 23. PLoS One. 2011. PMID: 21629792 Free PMC article.

2

Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C.

Boije af Gennäs G, Talman V, Aitio O, Ekokoski E, Finel M, Tuominen RK, Yli-Kauhaluoma J. Boije af Gennäs G, et al. Among authors: talman v. J Med Chem. 2009 Jul 9;52(13):3969-81. doi: 10.1021/jm900229p. J Med Chem. 2009. PMID: 19438240 Free article.

3

Current status and future prospects of C1 domain ligands as drug candidates.

Boije af Gennäs G, Talman V, Yli-Kauhaluoma J, Tuominen RK, Ekokoski E. Boije af Gennäs G, et al. Among authors: talman v. Curr Top Med Chem. 2011;11(11):1370-92. doi: 10.2174/156802611795589584. Curr Top Med Chem. 2011. PMID: 21513495 Free article. Review.

4

The C1 domain-targeted isophthalate derivative HMI-1b11 promotes neurite outgrowth and GAP-43 expression through PKCα activation in SH-SY5Y cells.

Talman V, Amadio M, Osera C, Sorvari S, Boije Af Gennäs G, Yli-Kauhaluoma J, Rossi D, Govoni S, Collina S, Ekokoski E, Tuominen RK, Pascale A. Talman V, et al. Pharmacol Res. 2013 Jul;73:44-54. doi: 10.1016/j.phrs.2013.04.008. Epub 2013 May 3. Pharmacol Res. 2013. PMID: 23643828

5

Evidence for a role of MRCK in mediating HeLa cell elongation induced by the C1 domain ligand HMI-1a3.

Talman V, Gateva G, Ahti M, Ekokoski E, Lappalainen P, Tuominen RK. Talman V, et al. Eur J Pharm Sci. 2014 May 13;55:46-57. doi: 10.1016/j.ejps.2014.01.002. Epub 2014 Jan 29. Eur J Pharm Sci. 2014. PMID: 24486483 Free article.

6

C1 domain-targeted isophthalates as protein kinase C modulators: structure-based design, structure-activity relationships and biological activities.

Talman V, Provenzani R, Boije af Gennäs G, Tuominen RK, Yli-Kauhaluoma J. Talman V, et al. Biochem Soc Trans. 2014 Dec;42(6):1543-9. doi: 10.1042/BST20140181. Biochem Soc Trans. 2014. PMID: 25399568

7

Protein Kinase C Activation as a Potential Therapeutic Strategy in Alzheimer's Disease: Is there a Role for Embryonic Lethal Abnormal Vision-like Proteins?

Talman V, Pascale A, Jäntti M, Amadio M, Tuominen RK. Talman V, et al. Basic Clin Pharmacol Toxicol. 2016 Aug;119(2):149-60. doi: 10.1111/bcpt.12581. Epub 2016 Apr 29. Basic Clin Pharmacol Toxicol. 2016. PMID: 27001133 Free article. Review.

8

Scaffold hopping from (5-hydroxymethyl) isophthalates to multisubstituted pyrimidines diminishes binding affinity to the C1 domain of protein kinase C.

Provenzani R, Tarvainen I, Brandoli G, Lempinen A, Artes S, Turku A, Jäntti MH, Talman V, Yli-Kauhaluoma J, Tuominen RK, Boije Af Gennäs G. Provenzani R, et al. Among authors: talman v. PLoS One. 2018 Apr 11;13(4):e0195668. doi: 10.1371/journal.pone.0195668. eCollection 2018. PLoS One. 2018. PMID: 29641588 Free PMC article.

9

Anticancer activity of the protein kinase C modulator HMI-1a3 in 2D and 3D cell culture models of androgen-responsive and androgen-unresponsive prostate cancer.

Jäntti MH, Talman V, Räsänen K, Tarvainen I, Koistinen H, Tuominen RK. Jäntti MH, et al. Among authors: talman v. FEBS Open Bio. 2018 Apr 17;8(5):817-828. doi: 10.1002/2211-5463.12419. eCollection 2018 May. FEBS Open Bio. 2018. PMID: 29744295 Free PMC article.

10

Stem cells are the most sensitive screening tool to identify toxicity of GATA4-targeted novel small-molecule compounds.

Karhu ST, Välimäki MJ, Jumppanen M, Kinnunen SM, Pohjolainen L, Leigh RS, Auno S, Földes G, Boije Af Gennäs G, Yli-Kauhaluoma J, Ruskoaho H, Talman V. Karhu ST, et al. Among authors: talman v. Arch Toxicol. 2018 Sep;92(9):2897-2911. doi: 10.1007/s00204-018-2257-1. Epub 2018 Jul 9. Arch Toxicol. 2018. PMID: 29987409 Free PMC article.

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