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Amplification and translocation of 3q26 with overexpression of EVI1 in Fanconi anemia-derived childhood acute myeloid leukemia with biallelic FANCD1/BRCA2 disruption.
Meyer S, Fergusson WD, Whetton AD, Moreira-Leite F, Pepper SD, Miller C, Saunders EK, White DJ, Will AM, Eden T, Ikeda H, Ullmann R, Tuerkmen S, Gerlach A, Klopocki E, Tönnies H. Meyer S, et al. Genes Chromosomes Cancer. 2007 Apr;46(4):359-72. doi: 10.1002/gcc.20417. Genes Chromosomes Cancer. 2007. PMID: 17243162
Phosphorylation of the leukemic oncoprotein EVI1 on serine 196 modulates DNA binding, transcriptional repression and transforming ability.
White DJ, Unwin RD, Bindels E, Pierce A, Teng HY, Muter J, Greystoke B, Somerville TD, Griffiths J, Lovell S, Somervaille TC, Delwel R, Whetton AD, Meyer S. White DJ, et al. Among authors: meyer s. PLoS One. 2013 Jun 12;8(6):e66510. doi: 10.1371/journal.pone.0066510. Print 2013. PLoS One. 2013. PMID: 23776681 Free PMC article.
EVI1 phosphorylation at S436 regulates interactions with CtBP1 and DNMT3A and promotes self-renewal.
Paredes R, Kelly JR, Geary B, Almarzouq B, Schneider M, Pearson S, Narayanan P, Williamson A, Lovell SC, Wiseman DH, Chadwick JA, Jones NJ, Kustikova O, Schambach A, Garner T, Amaral FMR, Pierce A, Stevens A, Somervaille TCP, Whetton AD, Meyer S. Paredes R, et al. Among authors: meyer s. Cell Death Dis. 2020 Oct 20;11(10):878. doi: 10.1038/s41419-020-03099-0. Cell Death Dis. 2020. PMID: 33082307 Free PMC article.
EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association.
Paredes R, Schneider M, Stevens A, White DJ, Williamson AJK, Muter J, Pearson S, Kelly JR, Connors K, Wiseman DH, Chadwick JA, Löffler H, Teng HY, Lovell S, Unwin R, van de Vrugt HJ, Smith H, Kustikova O, Schambach A, Somervaille TCP, Pierce A, Whetton AD, Meyer S. Paredes R, et al. Among authors: meyer s. Nucleic Acids Res. 2018 Sep 6;46(15):7662-7674. doi: 10.1093/nar/gky536. Nucleic Acids Res. 2018. PMID: 29939287 Free PMC article.
Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1.
Lugthart S, Figueroa ME, Bindels E, Skrabanek L, Valk PJ, Li Y, Meyer S, Erpelinck-Verschueren C, Greally J, Löwenberg B, Melnick A, Delwel R. Lugthart S, et al. Among authors: meyer s. Blood. 2011 Jan 6;117(1):234-41. doi: 10.1182/blood-2010-04-281337. Epub 2010 Sep 20. Blood. 2011. PMID: 20855866 Free PMC article.
3,202 results