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Borderzone contractile dysfunction is transiently attenuated and left ventricular structural remodeling is markedly reduced following reperfused myocardial infarction in inducible nitric oxide synthase knockout mice.
Gilson WD, Epstein FH, Yang Z, Xu Y, Prasad KM, Toufektsian MC, Laubach VE, French BA. Gilson WD, et al. Among authors: xu y. J Am Coll Cardiol. 2007 Oct 30;50(18):1799-807. doi: 10.1016/j.jacc.2007.07.047. J Am Coll Cardiol. 2007. PMID: 17964046 Free article.
Adeno-associated virus serotype 9 administered systemically after reperfusion preferentially targets cardiomyocytes in the infarct border zone with pharmacodynamics suitable for the attenuation of left ventricular remodeling.
Konkalmatt PR, Wang F, Piras BA, Xu Y, O'Connor DM, Beyers RJ, Epstein FH, Annex BH, Hossack JA, French BA. Konkalmatt PR, et al. Among authors: xu y. J Gene Med. 2012 Sep-Oct;14(9-10):609-20. doi: 10.1002/jgm.2673. J Gene Med. 2012. PMID: 23065925 Free PMC article.
Cardiac-selective expression of extracellular superoxide dismutase after systemic injection of adeno-associated virus 9 protects the heart against post-myocardial infarction left ventricular remodeling.
Konkalmatt PR, Beyers RJ, O'Connor DM, Xu Y, Seaman ME, French BA. Konkalmatt PR, et al. Among authors: xu y. Circ Cardiovasc Imaging. 2013 May 1;6(3):478-86. doi: 10.1161/CIRCIMAGING.112.000320. Epub 2013 Mar 27. Circ Cardiovasc Imaging. 2013. PMID: 23536266 Free PMC article.
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