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Caspase-14 is required for filaggrin degradation to natural moisturizing factors in the skin.
Hoste E, Kemperman P, Devos M, Denecker G, Kezic S, Yau N, Gilbert B, Lippens S, De Groote P, Roelandt R, Van Damme P, Gevaert K, Presland RB, Takahara H, Puppels G, Caspers P, Vandenabeele P, Declercq W. Hoste E, et al. Among authors: kezic s. J Invest Dermatol. 2011 Nov;131(11):2233-41. doi: 10.1038/jid.2011.153. Epub 2011 Jun 9. J Invest Dermatol. 2011. PMID: 21654840 Free article.
Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency.
Kezic S, O'Regan GM, Lutter R, Jakasa I, Koster ES, Saunders S, Caspers P, Kemperman PM, Puppels GJ, Sandilands A, Chen H, Campbell LE, Kroboth K, Watson R, Fallon PG, McLean WH, Irvine AD. Kezic S, et al. J Allergy Clin Immunol. 2012 Apr;129(4):1031-9.e1. doi: 10.1016/j.jaci.2011.12.989. Epub 2012 Feb 8. J Allergy Clin Immunol. 2012. PMID: 22322004 Free PMC article.
Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients.
Janssens M, van Smeden J, Gooris GS, Bras W, Portale G, Caspers PJ, Vreeken RJ, Hankemeier T, Kezic S, Wolterbeek R, Lavrijsen AP, Bouwstra JA. Janssens M, et al. Among authors: kezic s. J Lipid Res. 2012 Dec;53(12):2755-66. doi: 10.1194/jlr.P030338. Epub 2012 Sep 28. J Lipid Res. 2012. PMID: 23024286 Free PMC article.
226 results