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Page 1
Identification of non-amidine inhibitors of acid-sensing ion channel-3 (ASIC3).
Kuduk SD, Chang RK, Di Marco CN, Dipardo RM, Cook SP, Cato MJ, Jovanovska A, Urban MO, Leitl M, Spencer RH, Kane SA, Hartman GD, Bilodeau MT. Kuduk SD, et al. Among authors: spencer rh. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4255-8. doi: 10.1016/j.bmcl.2011.05.064. Epub 2011 May 27. Bioorg Med Chem Lett. 2011. PMID: 21669528
Potent antagonists of the Kv1.5 potassium channel: synthesis and evaluation of analogous N,N-diisopropyl-2-(pyridine-3-yl)acetamides.
Nanda KK, Nolt MB, Cato MJ, Kane SA, Kiss L, Spencer RH, Wang J, Lynch JJ, Regan CP, Stump GL, Li B, White R, Yeh S, Bogusky MJ, Bilodeau MT, Dinsmore CJ, Lindsley CW, Hartman GD, Wolkenberg SE, Trotter BW. Nanda KK, et al. Among authors: spencer rh. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5897-901. doi: 10.1016/j.bmcl.2006.08.054. Epub 2006 Sep 1. Bioorg Med Chem Lett. 2006. PMID: 16949818
Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3).
Kuduk SD, Di Marco CN, Chang RK, Dipardo RM, Cook SP, Cato MJ, Jovanovska A, Urban MO, Leitl M, Spencer RH, Kane SA, Bilodeau MT, Hartman GD, Bock MG. Kuduk SD, et al. Among authors: spencer rh. Bioorg Med Chem Lett. 2009 May 1;19(9):2514-8. doi: 10.1016/j.bmcl.2009.03.029. Epub 2009 Mar 14. Bioorg Med Chem Lett. 2009. PMID: 19339181
Amidine derived inhibitors of acid-sensing ion channel-3 (ASIC3).
Kuduk SD, Chang RK, Wai JM, Di Marco CN, Cofre V, DiPardo RM, Cook SP, Cato MJ, Jovanovska A, Urban MO, Leitl M, Spencer RH, Kane SA, Hartman GD, Bilodeau MT. Kuduk SD, et al. Among authors: spencer rh. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4059-63. doi: 10.1016/j.bmcl.2009.06.021. Epub 2009 Jun 13. Bioorg Med Chem Lett. 2009. PMID: 19553111
Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel.
Beshore DC, Liverton NJ, McIntyre CJ, Claiborne CF, Libby B, Culberson JC, Salata JJ, Regan CP, Lynch JJ, Kiss L, Spencer RH, Kane SA, White RB, Yeh S, Hartman GD, Dinsmore CJ. Beshore DC, et al. Among authors: spencer rh. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2493-6. doi: 10.1016/j.bmcl.2010.03.005. Epub 2010 Mar 4. Bioorg Med Chem Lett. 2010. PMID: 20304642
Synthesis, structure-activity relationship, and pharmacological profile of analogs of the ASIC-3 inhibitor A-317567.
Kuduk SD, Di Marco CN, Bodmer-Narkevitch V, Cook SP, Cato MJ, Jovanovska A, Urban MO, Leitl M, Sain N, Liang A, Spencer RH, Kane SA, Hartman GD, Bilodeau MT. Kuduk SD, et al. Among authors: spencer rh. ACS Chem Neurosci. 2010 Jan 20;1(1):19-24. doi: 10.1021/cn9000186. Epub 2009 Oct 6. ACS Chem Neurosci. 2010. PMID: 22778804 Free PMC article.
Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics.
Wolkenberg SE, Nolt MB, Bilodeau MT, Trotter BW, Manley PJ, Kett NR, Nanda KK, Wu Z, Cato MJ, Kane SA, Kiss L, Spencer RH, Wang J, Lynch JJ, Regan CP, Stump GL, Li B, White R, Yeh S, Dinsmore CJ, Lindsley CW, Hartman GD. Wolkenberg SE, et al. Among authors: spencer rh. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1062-1069. doi: 10.1016/j.bmcl.2016.12.054. Epub 2017 Jan 16. Bioorg Med Chem Lett. 2017. PMID: 28131713
Design and synthesis of novel isoquinoline-3-nitriles as orally bioavailable Kv1.5 antagonists for the treatment of atrial fibrillation.
Trotter BW, Nanda KK, Kett NR, Regan CP, Lynch JJ, Stump GL, Kiss L, Wang J, Spencer RH, Kane SA, White RB, Zhang R, Anderson KD, Liverton NJ, McIntyre CJ, Beshore DC, Hartman GD, Dinsmore CJ. Trotter BW, et al. Among authors: spencer rh. J Med Chem. 2006 Nov 30;49(24):6954-7. doi: 10.1021/jm060927v. J Med Chem. 2006. PMID: 17125248
39 results