Rauh D - Search Results

1

Identification of Ustilago maydis Aurora kinase as a novel antifungal target.

Tückmantel S, Greul JN, Janning P, Brockmeyer A, Grütter C, Simard JR, Gutbrod O, Beck ME, Tietjen K, Rauh D, Schreier PH. Tückmantel S, et al. Among authors: rauh d. ACS Chem Biol. 2011 Sep 16;6(9):926-33. doi: 10.1021/cb200112y. Epub 2011 Jun 20. ACS Chem Biol. 2011. PMID: 21671622

2

Structural insights into how irreversible inhibitors can overcome drug resistance in EGFR.

Michalczyk A, Klüter S, Rode HB, Simard JR, Grütter C, Rabiller M, Rauh D. Michalczyk A, et al. Among authors: rauh d. Bioorg Med Chem. 2008 Apr 1;16(7):3482-8. doi: 10.1016/j.bmc.2008.02.053. Epub 2008 Feb 20. Bioorg Med Chem. 2008. PMID: 18316192

3

A new screening assay for allosteric inhibitors of cSrc.

Simard JR, Klüter S, Grütter C, Getlik M, Rabiller M, Rode HB, Rauh D. Simard JR, et al. Among authors: rauh d. Nat Chem Biol. 2009 Jun;5(6):394-6. doi: 10.1038/nchembio.162. Epub 2009 Apr 26. Nat Chem Biol. 2009. PMID: 19396179

4

Hybrid compound design to overcome the gatekeeper T338M mutation in cSrc.

Getlik M, Grütter C, Simard JR, Klüter S, Rabiller M, Rode HB, Robubi A, Rauh D. Getlik M, et al. Among authors: rauh d. J Med Chem. 2009 Jul 9;52(13):3915-26. doi: 10.1021/jm9002928. J Med Chem. 2009. PMID: 19462975

5

Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors.

Simard JR, Getlik M, Grütter C, Pawar V, Wulfert S, Rabiller M, Rauh D. Simard JR, et al. Among authors: rauh d. J Am Chem Soc. 2009 Sep 23;131(37):13286-96. doi: 10.1021/ja902010p. J Am Chem Soc. 2009. PMID: 19572644

6

Chemical and structural biology to direct the repurposing of sulindac.

Simard JR, Rauh D. Simard JR, et al. Among authors: rauh d. ChemMedChem. 2009 Nov;4(11):1793-5. doi: 10.1002/cmdc.200900384. ChemMedChem. 2009. PMID: 19802856 No abstract available.

7

Displacement assay for the detection of stabilizers of inactive kinase conformations.

Klüter S, Grütter C, Naqvi T, Rabiller M, Simard JR, Pawar V, Getlik M, Rauh D. Klüter S, et al. Among authors: rauh d. J Med Chem. 2010 Jan 14;53(1):357-67. doi: 10.1021/jm901297e. J Med Chem. 2010. PMID: 19928858

8

High-throughput screening to identify inhibitors which stabilize inactive kinase conformations in p38alpha.

Simard JR, Grütter C, Pawar V, Aust B, Wolf A, Rabiller M, Wulfert S, Robubi A, Klüter S, Ottmann C, Rauh D. Simard JR, et al. Among authors: rauh d. J Am Chem Soc. 2009 Dec 30;131(51):18478-88. doi: 10.1021/ja907795q. J Am Chem Soc. 2009. PMID: 19950957

9

Chemogenomic profiling provides insights into the limited activity of irreversible EGFR Inhibitors in tumor cells expressing the T790M EGFR resistance mutation.

Sos ML, Rode HB, Heynck S, Peifer M, Fischer F, Klüter S, Pawar VG, Reuter C, Heuckmann JM, Weiss J, Ruddigkeit L, Rabiller M, Koker M, Simard JR, Getlik M, Yuza Y, Chen TH, Greulich H, Thomas RK, Rauh D. Sos ML, et al. Among authors: rauh d. Cancer Res. 2010 Feb 1;70(3):868-74. doi: 10.1158/0008-5472.CAN-09-3106. Epub 2010 Jan 26. Cancer Res. 2010. PMID: 20103621 Free article.

10

Fluorophore labeling of the glycine-rich loop as a method of identifying inhibitors that bind to active and inactive kinase conformations.

Simard JR, Getlik M, Grütter C, Schneider R, Wulfert S, Rauh D. Simard JR, et al. Among authors: rauh d. J Am Chem Soc. 2010 Mar 31;132(12):4152-60. doi: 10.1021/ja908083e. J Am Chem Soc. 2010. PMID: 20201574

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