Morelli X - Search Results

1

Chemical and structural lessons from recent successes in protein-protein interaction inhibition (2P2I).

Morelli X, Bourgeas R, Roche P. Morelli X, et al. Curr Opin Chem Biol. 2011 Aug;15(4):475-81. doi: 10.1016/j.cbpa.2011.05.024. Epub 2011 Jun 22. Curr Opin Chem Biol. 2011. PMID: 21684802 Review.

2

Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein.

Betzi S, Restouin A, Opi S, Arold ST, Parrot I, Guerlesquin F, Morelli X, Collette Y. Betzi S, et al. Among authors: morelli x. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19256-61. doi: 10.1073/pnas.0707130104. Epub 2007 Nov 27. Proc Natl Acad Sci U S A. 2007. PMID: 18042718 Free PMC article.

3

Protein-protein interaction inhibition (2P2I): fewer and fewer undruggable targets.

Betzi S, Guerlesquin F, Morelli X. Betzi S, et al. Among authors: morelli x. Comb Chem High Throughput Screen. 2009 Dec;12(10):968-83. doi: 10.2174/138620709789824736. Comb Chem High Throughput Screen. 2009. PMID: 20025563 Review.

4

Modified cap group suberoylanilide hydroxamic acid histone deacetylase inhibitor derivatives reveal improved selective antileukemic activity.

Salmi-Smail C, Fabre A, Dequiedt F, Restouin A, Castellano R, Garbit S, Roche P, Morelli X, Brunel JM, Collette Y. Salmi-Smail C, et al. Among authors: morelli x. J Med Chem. 2010 Apr 22;53(8):3038-47. doi: 10.1021/jm901358y. J Med Chem. 2010. PMID: 20218673 Free article.

5

Atomic analysis of protein-protein interfaces with known inhibitors: the 2P2I database.

Bourgeas R, Basse MJ, Morelli X, Roche P. Bourgeas R, et al. Among authors: morelli x. PLoS One. 2010 Mar 9;5(3):e9598. doi: 10.1371/journal.pone.0009598. PLoS One. 2010. PMID: 20231898 Free PMC article.

6

An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity.

El Turk F, Fauvet B, Ouertatani-Sakouhi H, Lugari A, Betzi S, Roche P, Morelli X, Lashuel HA. El Turk F, et al. Among authors: morelli x. Bioorg Med Chem. 2010 Jul 15;18(14):5425-40. doi: 10.1016/j.bmc.2010.05.010. Epub 2010 May 13. Bioorg Med Chem. 2010. PMID: 20639113 Free article.

7

2P2Idb: a structural database dedicated to orthosteric modulation of protein-protein interactions.

Basse MJ, Betzi S, Bourgeas R, Bouzidi S, Chetrit B, Hamon V, Morelli X, Roche P. Basse MJ, et al. Among authors: morelli x. Nucleic Acids Res. 2013 Jan;41(Database issue):D824-7. doi: 10.1093/nar/gks1002. Epub 2012 Nov 30. Nucleic Acids Res. 2013. PMID: 23203891 Free PMC article.

8

Stereoselective synthesis of original spirolactams displaying promising folded structures.

Chaubet G, Coursindel T, Morelli X, Betzi S, Roche P, Guari Y, Lebrun A, Toupet L, Collette Y, Parrot I, Martinez J. Chaubet G, et al. Among authors: morelli x. Org Biomol Chem. 2013 Jul 28;11(28):4719-26. doi: 10.1039/c3ob40643a. Epub 2013 Jun 13. Org Biomol Chem. 2013. PMID: 23760068 Free article.

9

2P2I HUNTER: a tool for filtering orthosteric protein-protein interaction modulators via a dedicated support vector machine.

Hamon V, Bourgeas R, Ducrot P, Theret I, Xuereb L, Basse MJ, Brunel JM, Combes S, Morelli X, Roche P. Hamon V, et al. Among authors: morelli x. J R Soc Interface. 2013 Nov 6;11(90):20130860. doi: 10.1098/rsif.2013.0860. Print 2014 Jan 6. J R Soc Interface. 2013. PMID: 24196694 Free PMC article.

10

Focused chemical libraries--design and enrichment: an example of protein-protein interaction chemical space.

Zhang X, Betzi S, Morelli X, Roche P. Zhang X, et al. Among authors: morelli x. Future Med Chem. 2014 Jul;6(11):1291-307. doi: 10.4155/fmc.14.57. Epub 2014 Apr 28. Future Med Chem. 2014. PMID: 24773599 Review.

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