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522 results

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Safety pharmacology in 2010 and beyond: survey of significant events of the past 10 years and a roadmap to the immediate-, intermediate- and long-term future in recognition of the tenth anniversary of the Safety Pharmacology Society.
Bass AS, Vargas HM, Valentin JP, Kinter LB, Hammond T, Wallis R, Siegl PK, Yamamoto K. Bass AS, et al. Among authors: wallis r. J Pharmacol Toxicol Methods. 2011 Jul-Aug;64(1):7-15. doi: 10.1016/j.vascn.2011.05.006. Epub 2011 Jun 12. J Pharmacol Toxicol Methods. 2011. PMID: 21689769 Review.
A framework to assess the translation of safety pharmacology data to humans.
Valentin JP, Bialecki R, Ewart L, Hammond T, Leishmann D, Lindgren S, Martinez V, Pollard C, Redfern W, Wallis R. Valentin JP, et al. Among authors: wallis r. J Pharmacol Toxicol Methods. 2009 Sep-Oct;60(2):152-8. doi: 10.1016/j.vascn.2009.05.011. Epub 2009 Jul 17. J Pharmacol Toxicol Methods. 2009. PMID: 19616110
How do the top 12 pharmaceutical companies operate safety pharmacology?
Ewart L, Gallacher DJ, Gintant G, Guillon JM, Leishman D, Levesque P, McMahon N, Mylecraine L, Sanders M, Suter W, Wallis R, Valentin JP. Ewart L, et al. Among authors: wallis r. J Pharmacol Toxicol Methods. 2012 Sep;66(2):66-70. doi: 10.1016/j.vascn.2012.03.004. Epub 2012 Apr 1. J Pharmacol Toxicol Methods. 2012. PMID: 22510338
The concordance between nonclinical and phase I clinical cardiovascular assessment from a cross-company data sharing initiative.
Ewart L, Aylott M, Deurinck M, Engwall M, Gallacher DJ, Geys H, Jarvis P, Ju H, Leishman D, Leong L, McMahon N, Mead A, Milliken P, Suter W, Teisman A, Van Ammel K, Vargas HM, Wallis R, Valentin JP. Ewart L, et al. Among authors: wallis r. Toxicol Sci. 2014 Dec;142(2):427-35. doi: 10.1093/toxsci/kfu198. Epub 2014 Sep 21. Toxicol Sci. 2014. PMID: 25246669
Evaluating Associations Between Nonclinical Cardiovascular Functional Endpoints and Repeat-dose Cardiovascular Toxicity in the Beagle Dog: A Cross-company Initiative.
Milliken P, Aylott M, Edmunds N, Engle S, Ewart L, Fleurance R, Guffroy M, Hargreaves A, Heinz-Taheny K, Kirk S, Leishman D, Leong L, McMahon N, Valentin JP, Watson D, Wallis R, Clements P. Milliken P, et al. Among authors: wallis r. Toxicol Sci. 2020 Jul 1;176(1):224-235. doi: 10.1093/toxsci/kfaa051. Toxicol Sci. 2020. PMID: 32298455
How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?
Laverty H, Benson C, Cartwright E, Cross M, Garland C, Hammond T, Holloway C, McMahon N, Milligan J, Park B, Pirmohamed M, Pollard C, Radford J, Roome N, Sager P, Singh S, Suter T, Suter W, Trafford A, Volders P, Wallis R, Weaver R, York M, Valentin J. Laverty H, et al. Among authors: wallis r. Br J Pharmacol. 2011 Jun;163(4):675-93. doi: 10.1111/j.1476-5381.2011.01255.x. Br J Pharmacol. 2011. PMID: 21306581 Free PMC article. Review.
Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development.
Redfern WS, Carlsson L, Davis AS, Lynch WG, MacKenzie I, Palethorpe S, Siegl PK, Strang I, Sullivan AT, Wallis R, Camm AJ, Hammond TG. Redfern WS, et al. Among authors: wallis r. Cardiovasc Res. 2003 Apr 1;58(1):32-45. doi: 10.1016/s0008-6363(02)00846-5. Cardiovasc Res. 2003. PMID: 12667944 Review.
522 results