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Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells.
Udagawa N, Takahashi N, Akatsu T, Tanaka H, Sasaki T, Nishihara T, Koga T, Martin TJ, Suda T. Udagawa N, et al. Among authors: martin tj. Proc Natl Acad Sci U S A. 1990 Sep;87(18):7260-4. doi: 10.1073/pnas.87.18.7260. Proc Natl Acad Sci U S A. 1990. PMID: 2169622 Free PMC article.
Osteoblastic cells are involved in osteoclast formation.
Takahashi N, Akatsu T, Udagawa N, Sasaki T, Yamaguchi A, Moseley JM, Martin TJ, Suda T. Takahashi N, et al. Among authors: martin tj. Endocrinology. 1988 Nov;123(5):2600-2. doi: 10.1210/endo-123-5-2600. Endocrinology. 1988. PMID: 2844518
Osteoblasts/stromal cells stimulate osteoclast activation through expression of osteoclast differentiation factor/RANKL but not macrophage colony-stimulating factor: receptor activator of NF-kappa B ligand.
Udagawa N, Takahashi N, Jimi E, Matsuzaki K, Tsurukai T, Itoh K, Nakagawa N, Yasuda H, Goto M, Tsuda E, Higashio K, Gillespie MT, Martin TJ, Suda T. Udagawa N, et al. Among authors: martin tj. Bone. 1999 Nov;25(5):517-23. doi: 10.1016/s8756-3282(99)00210-0. Bone. 1999. PMID: 10574571
856 results