Baillie TA - Search Results

1

Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States.

Stepan AF, Walker DP, Bauman J, Price DA, Baillie TA, Kalgutkar AS, Aleo MD. Stepan AF, et al. Among authors: baillie ta. Chem Res Toxicol. 2011 Sep 19;24(9):1345-410. doi: 10.1021/tx200168d. Epub 2011 Jul 11. Chem Res Toxicol. 2011. PMID: 21702456 Review.

2

Metabolism and toxicity of drugs. Two decades of progress in industrial drug metabolism.

Baillie TA. Baillie TA. Chem Res Toxicol. 2008 Jan;21(1):129-37. doi: 10.1021/tx7002273. Epub 2007 Dec 4. Chem Res Toxicol. 2008. PMID: 18052111 Review.

3

Identification in rat bile of glutathione conjugates of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether, a nephrotoxic degradate of the anesthetic agent sevoflurane.

Jin L, Davis MR, Kharasch ED, Doss GA, Baillie TA. Jin L, et al. Among authors: baillie ta. Chem Res Toxicol. 1996 Mar;9(2):555-61. doi: 10.1021/tx950162m. Chem Res Toxicol. 1996. PMID: 8839062

4

Drug-protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development.

Evans DC, Watt AP, Nicoll-Griffith DA, Baillie TA. Evans DC, et al. Among authors: baillie ta. Chem Res Toxicol. 2004 Jan;17(1):3-16. doi: 10.1021/tx034170b. Chem Res Toxicol. 2004. PMID: 14727914 Review.

5

Approaches to mitigate the risk of serious adverse reactions in covalent drug design.

Baillie TA. Baillie TA. Expert Opin Drug Discov. 2021 Mar;16(3):275-287. doi: 10.1080/17460441.2021.1832079. Epub 2020 Oct 19. Expert Opin Drug Discov. 2021. PMID: 33006907 Review.

6

Biotransformation of the naturally occurring isothiocyanate sulforaphane in the rat: identification of phase I metabolites and glutathione conjugates.

Kassahun K, Davis M, Hu P, Martin B, Baillie T. Kassahun K, et al. Chem Res Toxicol. 1997 Nov;10(11):1228-33. doi: 10.1021/tx970080t. Chem Res Toxicol. 1997. PMID: 9403174

7

Glutathione-dependent metabolism of the antitumor agent sulofenur. Evidence for the formation of p-chlorophenyl isocyanate as a reactive intermediate.

Jochheim CM, Davis MR, Baillie KM, Ehlhardt WJ, Baillie TA. Jochheim CM, et al. Among authors: baillie km, baillie ta. Chem Res Toxicol. 2002 Feb;15(2):240-8. doi: 10.1021/tx0155698. Chem Res Toxicol. 2002. PMID: 11849051

8

Role of biotransformation in drug-induced toxicity: influence of intra- and inter-species differences in drug metabolism.

Baillie TA, Rettie AE. Baillie TA, et al. Drug Metab Pharmacokinet. 2011;26(1):15-29. doi: 10.2133/dmpk.dmpk-10-rv-089. Epub 2010 Oct 22. Drug Metab Pharmacokinet. 2011. PMID: 20978360 Free PMC article. Review.

9

Identification of novel glutathione conjugates of disulfiram and diethyldithiocarbamate in rat bile by liquid chromatography-tandem mass spectrometry. Evidence for metabolic activation of disulfiram in vivo.

Jin L, Davis MR, Hu P, Baillie TA. Jin L, et al. Among authors: baillie ta. Chem Res Toxicol. 1994 Jul-Aug;7(4):526-33. doi: 10.1021/tx00040a008. Chem Res Toxicol. 1994. PMID: 7981417

10

Mechanistic studies on the metabolic activation of acetaminophen in vivo.

Hoffmann KJ, Axworthy DB, Baillie TA. Hoffmann KJ, et al. Among authors: baillie ta. Chem Res Toxicol. 1990 May-Jun;3(3):204-11. doi: 10.1021/tx00015a004. Chem Res Toxicol. 1990. PMID: 2131832

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