Kelly BD - Search Results

1

A comparison of changes to doxorubicin pharmacokinetics, antitumor activity, and toxicity mediated by PEGylated dendrimer and PEGylated liposome drug delivery systems.

Kaminskas LM, McLeod VM, Kelly BD, Sberna G, Boyd BJ, Williamson M, Owen DJ, Porter CJ. Kaminskas LM, et al. Among authors: kelly bd. Nanomedicine. 2012 Jan;8(1):103-11. doi: 10.1016/j.nano.2011.05.013. Epub 2011 Jun 23. Nanomedicine. 2012. PMID: 21704192

2

Pharmacokinetics and tumor disposition of PEGylated, methotrexate conjugated poly-l-lysine dendrimers.

Kaminskas LM, Kelly BD, McLeod VM, Boyd BJ, Krippner GY, Williams ED, Porter CJ. Kaminskas LM, et al. Among authors: kelly bd. Mol Pharm. 2009 Jul-Aug;6(4):1190-204. doi: 10.1021/mp900049a. Mol Pharm. 2009. PMID: 19453158

3

PEGylation of polylysine dendrimers improves absorption and lymphatic targeting following SC administration in rats.

Kaminskas LM, Kota J, McLeod VM, Kelly BD, Karellas P, Porter CJ. Kaminskas LM, et al. Among authors: kelly bd. J Control Release. 2009 Dec 3;140(2):108-16. doi: 10.1016/j.jconrel.2009.08.005. Epub 2009 Aug 15. J Control Release. 2009. PMID: 19686787

4

Capping methotrexate α-carboxyl groups enhances systemic exposure and retains the cytotoxicity of drug conjugated PEGylated polylysine dendrimers.

Kaminskas LM, Kelly BD, McLeod VM, Sberna G, Boyd BJ, Owen DJ, Porter CJ. Kaminskas LM, et al. Among authors: kelly bd. Mol Pharm. 2011 Apr 4;8(2):338-49. doi: 10.1021/mp1001872. Epub 2011 Jan 21. Mol Pharm. 2011. PMID: 21171585

5

Characterisation and tumour targeting of PEGylated polylysine dendrimers bearing doxorubicin via a pH labile linker.

Kaminskas LM, Kelly BD, McLeod VM, Sberna G, Owen DJ, Boyd BJ, Porter CJ. Kaminskas LM, et al. Among authors: kelly bd. J Control Release. 2011 Jun 10;152(2):241-8. doi: 10.1016/j.jconrel.2011.02.005. Epub 2011 Feb 21. J Control Release. 2011. PMID: 21315119

6

Doxorubicin-conjugated PEGylated dendrimers show similar tumoricidal activity but lower systemic toxicity when compared to PEGylated liposome and solution formulations in mouse and rat tumor models.

Kaminskas LM, McLeod VM, Kelly BD, Cullinane C, Sberna G, Williamson M, Boyd BJ, Owen DJ, Porter CJ. Kaminskas LM, et al. Among authors: kelly bd. Mol Pharm. 2012 Mar 5;9(3):422-32. doi: 10.1021/mp200522d. Epub 2012 Jan 27. Mol Pharm. 2012. PMID: 22233281

7

Pulmonary administration of PEGylated polylysine dendrimers: absorption from the lung versus retention within the lung is highly size-dependent.

Ryan GM, Kaminskas LM, Kelly BD, Owen DJ, McIntosh MP, Porter CJ. Ryan GM, et al. Among authors: kelly bd. Mol Pharm. 2013 Aug 5;10(8):2986-95. doi: 10.1021/mp400091n. Epub 2013 Jun 26. Mol Pharm. 2013. PMID: 23750747

8

Pulmonary administration of a doxorubicin-conjugated dendrimer enhances drug exposure to lung metastases and improves cancer therapy.

Kaminskas LM, McLeod VM, Ryan GM, Kelly BD, Haynes JM, Williamson M, Thienthong N, Owen DJ, Porter CJ. Kaminskas LM, et al. Among authors: kelly bd. J Control Release. 2014 Jun 10;183:18-26. doi: 10.1016/j.jconrel.2014.03.012. Epub 2014 Mar 14. J Control Release. 2014. PMID: 24637466

9

Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumor-burdened lymph nodes after intravenous and subcutaneous administration in rats.

Kaminskas LM, McLeod VM, Ascher DB, Ryan GM, Jones S, Haynes JM, Trevaskis NL, Chan LJ, Sloan EK, Finnin BA, Williamson M, Velkov T, Williams ED, Kelly BD, Owen DJ, Porter CJ. Kaminskas LM, et al. Among authors: kelly bd. Mol Pharm. 2015 Feb 2;12(2):432-43. doi: 10.1021/mp500531e. Epub 2015 Jan 20. Mol Pharm. 2015. PMID: 25485615

10

Lymphatic transport and lymph node targeting of methotrexate-conjugated PEGylated dendrimers are enhanced by reducing the length of the drug linker or masking interactions with the injection site.

Ryan GM, McLeod VM, Mehta D, Kelly BD, Stanislawski PC, Owen DJ, Kaminskas LM, Porter CJH. Ryan GM, et al. Among authors: kelly bd. Nanomedicine. 2017 Nov;13(8):2485-2494. doi: 10.1016/j.nano.2017.08.003. Epub 2017 Aug 15. Nanomedicine. 2017. PMID: 28821463

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