Zhong W - Search Results

1

The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site.

Morgan HP, McNae IW, Nowicki MW, Zhong W, Michels PA, Auld DS, Fothergill-Gilmore LA, Walkinshaw MD. Morgan HP, et al. Among authors: zhong w. J Biol Chem. 2011 Sep 9;286(36):31232-40. doi: 10.1074/jbc.M110.212613. Epub 2011 Jul 5. J Biol Chem. 2011. PMID: 21733839 Free PMC article.

2

`In crystallo' substrate binding triggers major domain movements and reveals magnesium as a co-activator of Trypanosoma brucei pyruvate kinase.

Zhong W, Morgan HP, McNae IW, Michels PA, Fothergill-Gilmore LA, Walkinshaw MD. Zhong W, et al. Acta Crystallogr D Biol Crystallogr. 2013 Sep;69(Pt 9):1768-79. doi: 10.1107/S0907444913013875. Epub 2013 Aug 17. Acta Crystallogr D Biol Crystallogr. 2013. PMID: 23999300

3

Pyruvate kinases have an intrinsic and conserved decarboxylase activity.

Zhong W, Morgan HP, Nowicki MW, McNae IW, Yuan M, Bella J, Michels PA, Fothergill-Gilmore LA, Walkinshaw MD. Zhong W, et al. Biochem J. 2014 Mar 1;458(2):301-11. doi: 10.1042/BJ20130790. Biochem J. 2014. PMID: 24328825 Free article.

4

Structures of pyruvate kinases display evolutionarily divergent allosteric strategies.

Morgan HP, Zhong W, McNae IW, Michels PA, Fothergill-Gilmore LA, Walkinshaw MD. Morgan HP, et al. Among authors: zhong w. R Soc Open Sci. 2014 Sep 24;1(1):140120. doi: 10.1098/rsos.140120. eCollection 2014 Sep. R Soc Open Sci. 2014. PMID: 26064527 Free PMC article.

5

Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis.

Zhong W, Cui L, Goh BC, Cai Q, Ho P, Chionh YH, Yuan M, Sahili AE, Fothergill-Gilmore LA, Walkinshaw MD, Lescar J, Dedon PC. Zhong W, et al. Nat Commun. 2017 Dec 7;8(1):1986. doi: 10.1038/s41467-017-02086-y. Nat Commun. 2017. PMID: 29215013 Free PMC article.

6

Pyruvate Kinase Regulates the Pentose-Phosphate Pathway in Response to Hypoxia in Mycobacterium tuberculosis.

Zhong W, Guo J, Cui L, Chionh YH, Li K, El Sahili A, Cai Q, Yuan M, Michels PAM, Fothergill-Gilmore LA, Walkinshaw MD, Mu Y, Lescar J, Dedon PC. Zhong W, et al. J Mol Biol. 2019 Sep 6;431(19):3690-3705. doi: 10.1016/j.jmb.2019.07.033. Epub 2019 Aug 2. J Mol Biol. 2019. PMID: 31381898 Free article.

7

Pyruvate kinase from Plasmodium falciparum: Structural and kinetic insights into the allosteric mechanism.

Zhong W, Li K, Cai Q, Guo J, Yuan M, Wong YH, Walkinshaw MD, Fothergill-Gilmore LA, Michels PAM, Dedon PC, Lescar J. Zhong W, et al. Biochem Biophys Res Commun. 2020 Nov 12;532(3):370-376. doi: 10.1016/j.bbrc.2020.08.048. Epub 2020 Aug 30. Biochem Biophys Res Commun. 2020. PMID: 32878705

8

Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N¹)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.

Zhong W, Pasunooti KK, Balamkundu S, Wong YH, Nah Q, Gadi V, Gnanakalai S, Chionh YH, McBee ME, Gopal P, Lim SH, Olivier N, Buurman ET, Dick T, Liu CF, Lescar J, Dedon PC. Zhong W, et al. J Med Chem. 2019 Sep 12;62(17):7788-7805. doi: 10.1021/acs.jmedchem.9b00582. Epub 2019 Aug 29. J Med Chem. 2019. PMID: 31442049 Free PMC article.

9

Crystal structure and catalytic mechanism of the essential m¹G37 tRNA methyltransferase TrmD from Pseudomonas aeruginosa.

Jaroensuk J, Wong YH, Zhong W, Liew CW, Maenpuen S, Sahili AE, Atichartpongkul S, Chionh YH, Nah Q, Thongdee N, McBee ME, Prestwich EG, DeMott MS, Chaiyen P, Mongkolsuk S, Dedon PC, Lescar J, Fuangthong M. Jaroensuk J, et al. Among authors: zhong w. RNA. 2019 Nov;25(11):1481-1496. doi: 10.1261/rna.066746.118. Epub 2019 Aug 9. RNA. 2019. PMID: 31399541 Free PMC article.

10

Targeting the Bacterial Epitranscriptome for Antibiotic Development: Discovery of Novel tRNA-(N¹G37) Methyltransferase (TrmD) Inhibitors.

Zhong W, Koay A, Ngo A, Li Y, Nah Q, Wong YH, Chionh YH, Ng HQ, Koh-Stenta X, Poulsen A, Foo K, McBee M, Choong ML, El Sahili A, Kang C, Matter A, Lescar J, Hill J, Dedon P. Zhong W, et al. ACS Infect Dis. 2019 Mar 8;5(3):326-335. doi: 10.1021/acsinfecdis.8b00275. Epub 2019 Feb 4. ACS Infect Dis. 2019. PMID: 30682246

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