Mahara S - Search Results

1

The histone methyltransferase inhibitor, DZNep, up-regulates TXNIP, increases ROS production, and targets leukemia cells in AML.

Zhou J, Bi C, Cheong LL, Mahara S, Liu SC, Tay KG, Koh TL, Yu Q, Chng WJ. Zhou J, et al. Among authors: mahara s. Blood. 2011 Sep 8;118(10):2830-9. doi: 10.1182/blood-2010-07-294827. Epub 2011 Jul 6. Blood. 2011. PMID: 21734239 Free article.

2

PRL-3, a metastasis associated tyrosine phosphatase, is involved in FLT3-ITD signaling and implicated in anti-AML therapy.

Zhou J, Bi C, Chng WJ, Cheong LL, Liu SC, Mahara S, Tay KG, Zeng Q, Li J, Guo K, Tan CP, Yu H, Albert DH, Chen CS. Zhou J, et al. Among authors: mahara s. PLoS One. 2011 May 12;6(5):e19798. doi: 10.1371/journal.pone.0019798. PLoS One. 2011. PMID: 21589872 Free PMC article.

3

The pro-metastasis tyrosine phosphatase, PRL-3 (PTP4A3), is a novel mediator of oncogenic function of BCR-ABL in human chronic myeloid leukemia.

Zhou J, Cheong LL, Liu SC, Chong PS, Mahara S, Bi C, Ong KO, Zeng Q, Chng WJ. Zhou J, et al. Among authors: mahara s. Mol Cancer. 2012 Sep 21;11:72. doi: 10.1186/1476-4598-11-72. Mol Cancer. 2012. PMID: 22995644 Free PMC article.

4

HIFI-α activation underlies a functional switch in the paradoxical role of Ezh2/PRC2 in breast cancer.

Mahara S, Lee PL, Feng M, Tergaonkar V, Chng WJ, Yu Q. Mahara S, et al. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3735-44. doi: 10.1073/pnas.1602079113. Epub 2016 Jun 14. Proc Natl Acad Sci U S A. 2016. PMID: 27303043 Free PMC article.

5

Molecular switch of EZH2 in hypoxia.

Mahara S, Chng WJ, Yu Q. Mahara S, et al. Cell Cycle. 2016 Nov 16;15(22):3007-3008. doi: 10.1080/15384101.2016.1215699. Epub 2016 Jul 26. Cell Cycle. 2016. PMID: 27459028 Free PMC article. No abstract available.

6

Hypoxic tumor microenvironment activates GLI2 via HIF-1α and TGF-β2 to promote chemoresistance in colorectal cancer.

Tang YA, Chen YF, Bao Y, Mahara S, Yatim SMJM, Oguz G, Lee PL, Feng M, Cai Y, Tan EY, Fong SS, Yang ZH, Lan P, Wu XJ, Yu Q. Tang YA, et al. Among authors: mahara s. Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):E5990-E5999. doi: 10.1073/pnas.1801348115. Epub 2018 Jun 11. Proc Natl Acad Sci U S A. 2018. PMID: 29891662 Free PMC article.

7

Genome-scale CRISPR-Cas9 screen of Wnt/β-catenin signaling identifies therapeutic targets for colorectal cancer.

Wan C, Mahara S, Sun C, Doan A, Chua HK, Xu D, Bian J, Li Y, Zhu D, Sooraj D, Cierpicki T, Grembecka J, Firestein R. Wan C, et al. Among authors: mahara s. Sci Adv. 2021 May 19;7(21):eabf2567. doi: 10.1126/sciadv.abf2567. Print 2021 May. Sci Adv. 2021. PMID: 34138730 Free PMC article.

8

Targeting the seeds of small cell lung cancer.

Mahara S, Firestein R. Mahara S, et al. Ann Transl Med. 2017 Mar;5(5):113. doi: 10.21037/atm.2017.01.74. Ann Transl Med. 2017. PMID: 28361078 Free PMC article.

9

MED12 and BRD4 cooperate to sustain cancer growth upon loss of mediator kinase.

Sooraj D, Sun C, Doan A, Garama DJ, Dannappel MV, Zhu D, Chua HK, Mahara S, Wan Hassan WA, Tay YK, Guanizo A, Croagh D, Prodanovic Z, Gough DJ, Wan C, Firestein R. Sooraj D, et al. Among authors: mahara s. Mol Cell. 2022 Jan 6;82(1):123-139.e7. doi: 10.1016/j.molcel.2021.11.015. Epub 2021 Dec 14. Mol Cell. 2022. PMID: 34910943 Free article.

10

Transient promoter interactions modulate developmental gene activation.

Mahara S, Prüssing S, Smialkovska V, Krall S, Holliman S, Blum B, Dachtler V, Borgers H, Sollier E, Plass C, Feldmann A. Mahara S, et al. Mol Cell. 2024 Dec 5;84(23):4486-4502.e7. doi: 10.1016/j.molcel.2024.10.005. Epub 2024 Oct 29. Mol Cell. 2024. PMID: 39476844 Free article.

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