Ziarek JJ - Search Results

1

The CXC chemokine receptor 4 ligands ubiquitin and stromal cell-derived factor-1α function through distinct receptor interactions.

Saini V, Staren DM, Ziarek JJ, Nashaat ZN, Campbell EM, Volkman BF, Marchese A, Majetschak M. Saini V, et al. Among authors: ziarek jj. J Biol Chem. 2011 Sep 23;286(38):33466-77. doi: 10.1074/jbc.M111.233742. Epub 2011 Jul 13. J Biol Chem. 2011. PMID: 21757744 Free PMC article.

2

Ligands selectively tune the local and global motions of neurotensin receptor 1 (NTS₁).

Bumbak F, Pons M, Inoue A, Paniagua JC, Yan F, Wu H, Robson SA, Bathgate RAD, Scott DJ, Gooley PR, Ziarek JJ. Bumbak F, et al. Among authors: ziarek jj. Cell Rep. 2023 Jan 31;42(1):112015. doi: 10.1016/j.celrep.2023.112015. Epub 2023 Jan 20. Cell Rep. 2023. PMID: 36680775 Free PMC article.

3

Monomeric structure of the cardioprotective chemokine SDF-1/CXCL12.

Veldkamp CT, Ziarek JJ, Su J, Basnet H, Lennertz R, Weiner JJ, Peterson FC, Baker JE, Volkman BF. Veldkamp CT, et al. Among authors: ziarek jj. Protein Sci. 2009 Jul;18(7):1359-69. doi: 10.1002/pro.167. Protein Sci. 2009. PMID: 19551879 Free PMC article.

4

Targeting SDF-1/CXCL12 with a ligand that prevents activation of CXCR4 through structure-based drug design.

Veldkamp CT, Ziarek JJ, Peterson FC, Chen Y, Volkman BF. Veldkamp CT, et al. Among authors: ziarek jj. J Am Chem Soc. 2010 Jun 2;132(21):7242-3. doi: 10.1021/ja1002263. J Am Chem Soc. 2010. PMID: 20459090 Free PMC article.

5

Binding site identification and structure determination of protein-ligand complexes by NMR a semiautomated approach.

Ziarek JJ, Peterson FC, Lytle BL, Volkman BF. Ziarek JJ, et al. Methods Enzymol. 2011;493:241-75. doi: 10.1016/B978-0-12-381274-2.00010-8. Methods Enzymol. 2011. PMID: 21371594 Free PMC article.

6

Sulfotyrosine recognition as marker for druggable sites in the extracellular space.

Ziarek JJ, Heroux MS, Veldkamp CT, Peterson FC, Volkman BF. Ziarek JJ, et al. Int J Mol Sci. 2011;12(6):3740-56. doi: 10.3390/ijms12063740. Epub 2011 Jun 8. Int J Mol Sci. 2011. PMID: 21747703 Free PMC article.

7

Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways.

Drury LJ, Ziarek JJ, Gravel S, Veldkamp CT, Takekoshi T, Hwang ST, Heveker N, Volkman BF, Dwinell MB. Drury LJ, et al. Among authors: ziarek jj. Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17655-60. doi: 10.1073/pnas.1101133108. Epub 2011 Oct 11. Proc Natl Acad Sci U S A. 2011. PMID: 21990345 Free PMC article.

8

Structure-based ligand discovery for the protein-protein interface of chemokine receptor CXCR4.

Mysinger MM, Weiss DR, Ziarek JJ, Gravel S, Doak AK, Karpiak J, Heveker N, Shoichet BK, Volkman BF. Mysinger MM, et al. Among authors: ziarek jj. Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5517-22. doi: 10.1073/pnas.1120431109. Epub 2012 Mar 19. Proc Natl Acad Sci U S A. 2012. PMID: 22431600 Free PMC article.

9

A locked, dimeric CXCL12 variant effectively inhibits pulmonary metastasis of CXCR4-expressing melanoma cells due to enhanced serum stability.

Takekoshi T, Ziarek JJ, Volkman BF, Hwang ST. Takekoshi T, et al. Among authors: ziarek jj. Mol Cancer Ther. 2012 Nov;11(11):2516-25. doi: 10.1158/1535-7163.MCT-12-0494. Epub 2012 Aug 6. Mol Cancer Ther. 2012. PMID: 22869557 Free PMC article.

10

Heparin oligosaccharides inhibit chemokine (CXC motif) ligand 12 (CXCL12) cardioprotection by binding orthogonal to the dimerization interface, promoting oligomerization, and competing with the chemokine (CXC motif) receptor 4 (CXCR4) N terminus.

Ziarek JJ, Veldkamp CT, Zhang F, Murray NJ, Kartz GA, Liang X, Su J, Baker JE, Linhardt RJ, Volkman BF. Ziarek JJ, et al. J Biol Chem. 2013 Jan 4;288(1):737-46. doi: 10.1074/jbc.M112.394064. Epub 2012 Nov 12. J Biol Chem. 2013. PMID: 23148226 Free PMC article.

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