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Pharmacologic inhibition of ghrelin receptor signaling is insulin sparing and promotes insulin sensitivity.
Longo KA, Govek EK, Nolan A, McDonagh T, Charoenthongtrakul S, Giuliana DJ, Morgan K, Hixon J, Zhou C, Kelder B, Kopchick JJ, Saunders JO, Navia MA, Curtis R, DiStefano PS, Geddes BJ. Longo KA, et al. Among authors: mcdonagh t. J Pharmacol Exp Ther. 2011 Oct;339(1):115-24. doi: 10.1124/jpet.111.183764. Epub 2011 Jul 20. J Pharmacol Exp Ther. 2011. PMID: 21775475
The 24-hour respiratory quotient predicts energy intake and changes in body mass.
Longo KA, Charoenthongtrakul S, Giuliana DJ, Govek EK, McDonagh T, Distefano PS, Geddes BJ. Longo KA, et al. Among authors: mcdonagh t. Am J Physiol Regul Integr Comp Physiol. 2010 Mar;298(3):R747-54. doi: 10.1152/ajpregu.00476.2009. Epub 2009 Dec 16. Am J Physiol Regul Integr Comp Physiol. 2010. PMID: 20018821 Free article.
Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.
Napper AD, Hixon J, McDonagh T, Keavey K, Pons JF, Barker J, Yau WT, Amouzegh P, Flegg A, Hamelin E, Thomas RJ, Kates M, Jones S, Navia MA, Saunders JO, DiStefano PS, Curtis R. Napper AD, et al. Among authors: mcdonagh t. J Med Chem. 2005 Dec 15;48(25):8045-54. doi: 10.1021/jm050522v. J Med Chem. 2005. PMID: 16335928
Substrate-specific activation of sirtuins by resveratrol.
Kaeberlein M, McDonagh T, Heltweg B, Hixon J, Westman EA, Caldwell SD, Napper A, Curtis R, DiStefano PS, Fields S, Bedalov A, Kennedy BK. Kaeberlein M, et al. Among authors: mcdonagh t. J Biol Chem. 2005 Apr 29;280(17):17038-45. doi: 10.1074/jbc.M500655200. Epub 2005 Jan 31. J Biol Chem. 2005. PMID: 15684413 Free article.
397 results