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Page 1
De novo design of diverse small molecule binders and sensors using Shape Complementary Pseudocycles.
An L, Said M, Tran L, Majumder S, Goreshnik I, Lee GR, Juergens D, Dauparas J, Anishchenko I, Coventry B, Bera AK, Kang A, Levine PM, Alvarez V, Pillai A, Norn C, Feldman D, Zorine D, Hicks DR, Li X, Sanchez MG, Vafeados DK, Salveson PJ, Vorobieva AA, Baker D. An L, et al. Among authors: goreshnik i. bioRxiv [Preprint]. 2023 Dec 21:2023.12.20.572602. doi: 10.1101/2023.12.20.572602. bioRxiv. 2023. Update in: Science. 2024 Jul 19;385(6706):276-282. doi: 10.1126/science.adn3780 PMID: 38187589 Free PMC article. Updated. Preprint.
Design of High Affinity Binders to Convex Protein Target Sites.
Yang W, Hicks DR, Ghosh A, Schwartze TA, Conventry B, Goreshnik I, Allen A, Halabiya SF, Kim CJ, Hinck CS, Lee DS, Bera AK, Li Z, Wang Y, Schlichthaerle T, Cao L, Huang B, Garrett S, Gerben SR, Rettie S, Heine P, Murray A, Edman N, Carter L, Stewart L, Almo S, Hinck AP, Baker D. Yang W, et al. Among authors: goreshnik i. bioRxiv [Preprint]. 2024 May 2:2024.05.01.592114. doi: 10.1101/2024.05.01.592114. bioRxiv. 2024. PMID: 38746206 Free PMC article. Preprint.
Atomically accurate de novo design of single-domain antibodies.
Bennett NR, Watson JL, Ragotte RJ, Borst AJ, See DL, Weidle C, Biswas R, Shrock EL, Leung PJY, Huang B, Goreshnik I, Ault R, Carr KD, Singer B, Criswell C, Vafeados D, Sanchez MG, Kim HM, Torres SV, Chan S, Baker D. Bennett NR, et al. Among authors: goreshnik i. bioRxiv [Preprint]. 2024 Mar 18:2024.03.14.585103. doi: 10.1101/2024.03.14.585103. bioRxiv. 2024. PMID: 38562682 Free PMC article. Preprint.
Small-molecule binding and sensing with a designed protein family.
Lee GR, Pellock SJ, Norn C, Tischer D, Dauparas J, Anischenko I, Mercer JAM, Kang A, Bera A, Nguyen H, Goreshnik I, Vafeados D, Roullier N, Han HL, Coventry B, Haddox HK, Liu DR, Yeh AH, Baker D. Lee GR, et al. Among authors: goreshnik i. bioRxiv [Preprint]. 2023 Nov 2:2023.11.01.565201. doi: 10.1101/2023.11.01.565201. bioRxiv. 2023. PMID: 37961294 Free PMC article. Preprint.
A computationally engineered RAS rheostat reveals RAS-ERK signaling dynamics.
Rose JC, Huang PS, Camp ND, Ye J, Leidal AM, Goreshnik I, Trevillian BM, Dickinson MS, Cunningham-Bryant D, Debnath J, Baker D, Wolf-Yadlin A, Maly DJ. Rose JC, et al. Among authors: goreshnik i. Nat Chem Biol. 2017 Jan;13(1):119-126. doi: 10.1038/nchembio.2244. Epub 2016 Nov 21. Nat Chem Biol. 2017. PMID: 27870838 Free PMC article.
Design of protein-binding proteins from the target structure alone.
Cao L, Coventry B, Goreshnik I, Huang B, Sheffler W, Park JS, Jude KM, Marković I, Kadam RU, Verschueren KHG, Verstraete K, Walsh STR, Bennett N, Phal A, Yang A, Kozodoy L, DeWitt M, Picton L, Miller L, Strauch EM, DeBouver ND, Pires A, Bera AK, Halabiya S, Hammerson B, Yang W, Bernard S, Stewart L, Wilson IA, Ruohola-Baker H, Schlessinger J, Lee S, Savvides SN, Garcia KC, Baker D. Cao L, et al. Among authors: goreshnik i. Nature. 2022 May;605(7910):551-560. doi: 10.1038/s41586-022-04654-9. Epub 2022 Mar 24. Nature. 2022. PMID: 35332283 Free PMC article.
29 results