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Page 1
Preparation of distinct ubiquitin chain reagents of high purity and yield.
Dong KC, Helgason E, Yu C, Phu L, Arnott DP, Bosanac I, Compaan DM, Huang OW, Fedorova AV, Kirkpatrick DS, Hymowitz SG, Dueber EC. Dong KC, et al. Among authors: huang ow. Structure. 2011 Aug 10;19(8):1053-63. doi: 10.1016/j.str.2011.06.010. Structure. 2011. PMID: 21827942 Free article.
Phosphorylation-dependent activity of the deubiquitinase DUBA.
Huang OW, Ma X, Yin J, Flinders J, Maurer T, Kayagaki N, Phung Q, Bosanac I, Arnott D, Dixit VM, Hymowitz SG, Starovasnik MA, Cochran AG. Huang OW, et al. Nat Struct Mol Biol. 2012 Jan 15;19(2):171-5. doi: 10.1038/nsmb.2206. Nat Struct Mol Biol. 2012. PMID: 22245969
Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells.
Rutz S, Kayagaki N, Phung QT, Eidenschenk C, Noubade R, Wang X, Lesch J, Lu R, Newton K, Huang OW, Cochran AG, Vasser M, Fauber BP, DeVoss J, Webster J, Diehl L, Modrusan Z, Kirkpatrick DS, Lill JR, Ouyang W, Dixit VM. Rutz S, et al. Among authors: huang ow. Nature. 2015 Feb 19;518(7539):417-21. doi: 10.1038/nature13979. Epub 2014 Dec 3. Nature. 2015. PMID: 25470037
Wnt antagonists bind through a short peptide to the first β-propeller domain of LRP5/6.
Bourhis E, Wang W, Tam C, Hwang J, Zhang Y, Spittler D, Huang OW, Gong Y, Estevez A, Zilberleyb I, Rouge L, Chiu C, Wu Y, Costa M, Hannoush RN, Franke Y, Cochran AG. Bourhis E, et al. Among authors: huang ow. Structure. 2011 Oct 12;19(10):1433-42. doi: 10.1016/j.str.2011.07.005. Epub 2011 Sep 22. Structure. 2011. PMID: 21944579 Free article.
Regulation of deubiquitinase proteolytic activity.
Huang OW, Cochran AG. Huang OW, et al. Curr Opin Struct Biol. 2013 Dec;23(6):806-11. doi: 10.1016/j.sbi.2013.07.012. Epub 2013 Aug 18. Curr Opin Struct Biol. 2013. PMID: 23962487 Review.
A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B.
Aliagas-Martin I, Burdick D, Corson L, Dotson J, Drummond J, Fields C, Huang OW, Hunsaker T, Kleinheinz T, Krueger E, Liang J, Moffat J, Phillips G, Pulk R, Rawson TE, Ultsch M, Walker L, Wiesmann C, Zhang B, Zhu BY, Cochran AG. Aliagas-Martin I, et al. Among authors: huang ow. J Med Chem. 2009 May 28;52(10):3300-7. doi: 10.1021/jm9000314. J Med Chem. 2009. PMID: 19402633
Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637).
Taylor AM, Côté A, Hewitt MC, Pastor R, Leblanc Y, Nasveschuk CG, Romero FA, Crawford TD, Cantone N, Jayaram H, Setser J, Murray J, Beresini MH, de Leon Boenig G, Chen Z, Conery AR, Cummings RT, Dakin LA, Flynn EM, Huang OW, Kaufman S, Keller PJ, Kiefer JR, Lai T, Li Y, Liao J, Liu W, Lu H, Pardo E, Tsui V, Wang J, Wang Y, Xu Z, Yan F, Yu D, Zawadzke L, Zhu X, Zhu X, Sims RJ 3rd, Cochran AG, Bellon S, Audia JE, Magnuson S, Albrecht BK. Taylor AM, et al. Among authors: huang ow. ACS Med Chem Lett. 2016 Mar 15;7(5):531-6. doi: 10.1021/acsmedchemlett.6b00075. eCollection 2016 May 12. ACS Med Chem Lett. 2016. PMID: 27190605 Free PMC article.
Covalent Degrader of the Oncogenic Transcription Factor β-Catenin.
Gowans FA, Forte N, Hatcher J, Huang OW, Wang Y, Altamirano Poblano BE, Wertz IE, Nomura DK. Gowans FA, et al. Among authors: huang ow. J Am Chem Soc. 2024 Jun 6. doi: 10.1021/jacs.4c05174. Online ahead of print. J Am Chem Soc. 2024. PMID: 38848252
13 results