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In silico docking and electrophysiological characterization of lacosamide binding sites on collapsin response mediator protein-2 identifies a pocket important in modulating sodium channel slow inactivation.
Wang Y, Brittain JM, Jarecki BW, Park KD, Wilson SM, Wang B, Hale R, Meroueh SO, Cummins TR, Khanna R. Wang Y, et al. Among authors: brittain jm. J Biol Chem. 2010 Aug 13;285(33):25296-307. doi: 10.1074/jbc.M110.128801. Epub 2010 Jun 9. J Biol Chem. 2010. PMID: 20538611 Free PMC article.
Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca²⁺ channel complex.
Brittain JM, Duarte DB, Wilson SM, Zhu W, Ballard C, Johnson PL, Liu N, Xiong W, Ripsch MS, Wang Y, Fehrenbacher JC, Fitz SD, Khanna M, Park CK, Schmutzler BS, Cheon BM, Due MR, Brustovetsky T, Ashpole NM, Hudmon A, Meroueh SO, Hingtgen CM, Brustovetsky N, Ji RR, Hurley JH, Jin X, Shekhar A, Xu XM, Oxford GS, Vasko MR, White FA, Khanna R. Brittain JM, et al. Nat Med. 2011 Jun 5;17(7):822-9. doi: 10.1038/nm.2345. Nat Med. 2011. PMID: 21642979 Free PMC article.
Further insights into the antinociceptive potential of a peptide disrupting the N-type calcium channel-CRMP-2 signaling complex.
Wilson SM, Brittain JM, Piekarz AD, Ballard CJ, Ripsch MS, Cummins TR, Hurley JH, Khanna M, Hammes NM, Samuels BC, White FA, Khanna R. Wilson SM, et al. Among authors: brittain jm. Channels (Austin). 2011 Sep-Oct;5(5):449-56. doi: 10.4161/chan.5.5.17363. Epub 2011 Sep 1. Channels (Austin). 2011. PMID: 21829088 Free PMC article.
Inhibition of transmitter release and attenuation of anti-retroviral-associated and tibial nerve injury-related painful peripheral neuropathy by novel synthetic Ca2+ channel peptides.
Wilson SM, Schmutzler BS, Brittain JM, Dustrude ET, Ripsch MS, Pellman JJ, Yeum TS, Hurley JH, Hingtgen CM, White FA, Khanna R. Wilson SM, et al. Among authors: brittain jm. J Biol Chem. 2012 Oct 12;287(42):35065-35077. doi: 10.1074/jbc.M112.378695. Epub 2012 Aug 13. J Biol Chem. 2012. PMID: 22891239 Free PMC article.
37 results