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Discovery of a brain-penetrant S1P₃-sparing direct agonist of the S1P₁ and S1P₅ receptors efficacious at low oral dose.
Demont EH, Arpino S, Bit RA, Campbell CA, Deeks N, Desai S, Dowell SJ, Gaskin P, Gray JR, Harrison LA, Haynes A, Heightman TD, Holmes DS, Humphreys PG, Kumar U, Morse MA, Osborne GJ, Panchal T, Philpott KL, Taylor S, Watson R, Willis R, Witherington J. Demont EH, et al. Among authors: philpott kl. J Med Chem. 2011 Oct 13;54(19):6724-33. doi: 10.1021/jm200609t. Epub 2011 Sep 9. J Med Chem. 2011. PMID: 21838322
Optimization of sphingosine-1-phosphate-1 receptor agonists: effects of acidic, basic, and zwitterionic chemotypes on pharmacokinetic and pharmacodynamic profiles.
Skidmore J, Heer J, Johnson CN, Norton D, Redshaw S, Sweeting J, Hurst D, Cridland A, Vesey D, Wall I, Ahmed M, Rivers D, Myatt J, Giblin G, Philpott K, Kumar U, Stevens A, Bit RA, Haynes A, Taylor S, Watson R, Witherington J, Demont E, Heightman TD. Skidmore J, et al. J Med Chem. 2014 Dec 26;57(24):10424-42. doi: 10.1021/jm5010336. Epub 2014 Dec 15. J Med Chem. 2014. PMID: 25431977
Caspase mRNA expression in a rat model of focal cerebral ischemia.
Harrison DC, Davis RP, Bond BC, Campbell CA, James MF, Parsons AA, Philpott KL. Harrison DC, et al. Among authors: philpott kl. Brain Res Mol Brain Res. 2001 Apr 18;89(1-2):133-46. doi: 10.1016/s0169-328x(01)00058-4. Brain Res Mol Brain Res. 2001. PMID: 11311984
AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1.
Muir AI, Chamberlain L, Elshourbagy NA, Michalovich D, Moore DJ, Calamari A, Szekeres PG, Sarau HM, Chambers JK, Murdock P, Steplewski K, Shabon U, Miller JE, Middleton SE, Darker JG, Larminie CG, Wilson S, Bergsma DJ, Emson P, Faull R, Philpott KL, Harrison DC. Muir AI, et al. Among authors: philpott kl. J Biol Chem. 2001 Aug 3;276(31):28969-75. doi: 10.1074/jbc.M102743200. Epub 2001 May 31. J Biol Chem. 2001. PMID: 11387329 Free article.
29 results