Hoever P - Search Results

1

Pharmacokinetics and tolerability of almorexant in Japanese and Caucasian healthy male subjects.

Hoch M, Hoever P, Alessi F, Marjason J, Dingemanse J. Hoch M, et al. Among authors: hoever p. Pharmacology. 2011;88(3-4):121-6. doi: 10.1159/000330098. Epub 2011 Aug 25. Pharmacology. 2011. PMID: 21865769 Clinical Trial.

2

Orexin receptor antagonism, a new sleep-promoting paradigm: an ascending single-dose study with almorexant.

Hoever P, de Haas S, Winkler J, Schoemaker RC, Chiossi E, van Gerven J, Dingemanse J. Hoever P, et al. Clin Pharmacol Ther. 2010 May;87(5):593-600. doi: 10.1038/clpt.2010.19. Epub 2010 Apr 7. Clin Pharmacol Ther. 2010. PMID: 20376002 Clinical Trial.

3

Food effect and biocomparison of two formulations of the dual orexin receptor antagonist almorexant in healthy male subjects.

Hoch M, Hoever P, Haschke M, Krähenbühl S, Dingemanse J. Hoch M, et al. Among authors: hoever p. J Clin Pharmacol. 2011 Jul;51(7):1116-21. doi: 10.1177/0091270010377634. Epub 2010 Sep 17. J Clin Pharmacol. 2011. PMID: 20852003 Clinical Trial. No abstract available.

4

Absolute oral bioavailability of almorexant, a dual orexin receptor antagonist, in healthy human subjects.

Hoch M, Hoever P, Zisowsky J, Priestley A, Fleet D, Dingemanse J. Hoch M, et al. Among authors: hoever p. Pharmacology. 2012;89(1-2):53-7. doi: 10.1159/000335367. Epub 2012 Feb 1. Pharmacology. 2012. PMID: 22302127 Clinical Trial.

5

Dual orexin receptor antagonism by almorexant does not potentiate impairing effects of alcohol in humans.

Hoch M, Hay JL, Hoever P, de Kam ML, te Beek ET, van Gerven JM, Dingemanse J. Hoch M, et al. Among authors: hoever p. Eur Neuropsychopharmacol. 2013 Feb;23(2):107-17. doi: 10.1016/j.euroneuro.2012.04.012. Epub 2012 May 30. Eur Neuropsychopharmacol. 2013. PMID: 22658401 Clinical Trial.

6

Orexin receptor antagonism: an ascending multiple-dose study with almorexant.

Hoever P, de Haas SL, Dorffner G, Chiossi E, van Gerven JM, Dingemanse J. Hoever P, et al. J Psychopharmacol. 2012 Aug;26(8):1071-80. doi: 10.1177/0269881112448946. Epub 2012 Jun 13. J Psychopharmacol. 2012. PMID: 22695489 Clinical Trial.

7

Pharmacokinetic interactions of almorexant with midazolam and simvastatin, two CYP3A4 model substrates, in healthy male subjects.

Hoch M, Hoever P, Alessi F, Theodor R, Dingemanse J. Hoch M, et al. Among authors: hoever p. Eur J Clin Pharmacol. 2013 Mar;69(3):523-32. doi: 10.1007/s00228-012-1403-6. Epub 2012 Sep 19. Eur J Clin Pharmacol. 2013. PMID: 22990330 Clinical Trial.

8

Almorexant effects on CYP3A4 activity studied by its simultaneous and time-separated administration with simvastatin and atorvastatin.

Hoch M, Hoever P, Theodor R, Dingemanse J. Hoch M, et al. Among authors: hoever p. Eur J Clin Pharmacol. 2013 Jun;69(6):1235-45. doi: 10.1007/s00228-012-1470-8. Epub 2013 Jan 20. Eur J Clin Pharmacol. 2013. PMID: 23334403 Clinical Trial.

9

Elucidation of the metabolic pathways and the resulting multiple metabolites of almorexant, a dual orexin receptor antagonist, in humans.

Dingemanse J, Hoever P, Hoch M, Treiber A, Wagner-Redeker W, Miraval T, Hopfgartner G, Shakeri-Nejad K. Dingemanse J, et al. Among authors: hoever p. Drug Metab Dispos. 2013 May;41(5):1046-59. doi: 10.1124/dmd.112.050120. Epub 2013 Feb 21. Drug Metab Dispos. 2013. PMID: 23431113

10

Tolerability, pharmacokinetics, and pharmacodynamics of single-dose almorexant, an orexin receptor antagonist, in healthy elderly subjects.

Hoever P, Hay J, Rad M, Cavallaro M, van Gerven JM, Dingemanse J. Hoever P, et al. J Clin Psychopharmacol. 2013 Jun;33(3):363-70. doi: 10.1097/JCP.0b013e31828f5a7a. J Clin Psychopharmacol. 2013. PMID: 23609389 Clinical Trial.

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