Trachootham D - Search Results

1

K-ras(G12V) transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis.

Hu Y, Lu W, Chen G, Wang P, Chen Z, Zhou Y, Ogasawara M, Trachootham D, Feng L, Pelicano H, Chiao PJ, Keating MJ, Garcia-Manero G, Huang P. Hu Y, et al. Among authors: trachootham d. Cell Res. 2012 Feb;22(2):399-412. doi: 10.1038/cr.2011.145. Epub 2011 Aug 30. Cell Res. 2012. PMID: 21876558 Free PMC article.

2

Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate.

Trachootham D, Zhou Y, Zhang H, Demizu Y, Chen Z, Pelicano H, Chiao PJ, Achanta G, Arlinghaus RB, Liu J, Huang P. Trachootham D, et al. Cancer Cell. 2006 Sep;10(3):241-52. doi: 10.1016/j.ccr.2006.08.009. Cancer Cell. 2006. PMID: 16959615 Free article.

3

Redox regulation of cell survival.

Trachootham D, Lu W, Ogasawara MA, Nilsa RD, Huang P. Trachootham D, et al. Antioxid Redox Signal. 2008 Aug;10(8):1343-74. doi: 10.1089/ars.2007.1957. Antioxid Redox Signal. 2008. PMID: 18522489 Free PMC article. Review.

4

Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism.

Trachootham D, Zhang H, Zhang W, Feng L, Du M, Zhou Y, Chen Z, Pelicano H, Plunkett W, Wierda WG, Keating MJ, Huang P. Trachootham D, et al. Blood. 2008 Sep 1;112(5):1912-22. doi: 10.1182/blood-2008-04-149815. Epub 2008 Jun 23. Blood. 2008. PMID: 18574029 Free PMC article.

5

Preferential killing of cancer cells with mitochondrial dysfunction by natural compounds.

Chen G, Wang F, Trachootham D, Huang P. Chen G, et al. Among authors: trachootham d. Mitochondrion. 2010 Nov;10(6):614-25. doi: 10.1016/j.mito.2010.08.001. Epub 2010 Aug 14. Mitochondrion. 2010. PMID: 20713185 Free PMC article. Review.

6

Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia.

Zhang W, Trachootham D, Liu J, Chen G, Pelicano H, Garcia-Prieto C, Lu W, Burger JA, Croce CM, Plunkett W, Keating MJ, Huang P. Zhang W, et al. Among authors: trachootham d. Nat Cell Biol. 2012 Feb 19;14(3):276-86. doi: 10.1038/ncb2432. Nat Cell Biol. 2012. PMID: 22344033 Free PMC article.

7

Alterations of cellular redox state during NNK-induced malignant transformation and resistance to radiation.

Demizu Y, Sasaki R, Trachootham D, Pelicano H, Colacino JA, Liu J, Huang P. Demizu Y, et al. Among authors: trachootham d. Antioxid Redox Signal. 2008 May;10(5):951-61. doi: 10.1089/ars.2007.1871. Antioxid Redox Signal. 2008. PMID: 18257743 Free PMC article.

8

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

Trachootham D, Alexandre J, Huang P. Trachootham D, et al. Nat Rev Drug Discov. 2009 Jul;8(7):579-91. doi: 10.1038/nrd2803. Epub 2009 May 29. Nat Rev Drug Discov. 2009. PMID: 19478820 Review.

9

Effective killing of Gleevec-resistant CML cells with T315I mutation by a natural compound PEITC through redox-mediated mechanism.

Zhang H, Trachootham D, Lu W, Carew J, Giles FJ, Keating MJ, Arlinghaus RB, Huang P. Zhang H, et al. Among authors: trachootham d. Leukemia. 2008 Jun;22(6):1191-9. doi: 10.1038/leu.2008.74. Epub 2008 Apr 3. Leukemia. 2008. PMID: 18385754 Free PMC article.

10

Loss of p53 in stromal fibroblasts promotes epithelial cell invasion through redox-mediated ICAM1 signal.

Trachootham D, Chen G, Zhang W, Lu W, Zhang H, Liu J, Huang P. Trachootham D, et al. Free Radic Biol Med. 2013 May;58:1-13. doi: 10.1016/j.freeradbiomed.2013.01.011. Epub 2013 Jan 29. Free Radic Biol Med. 2013. PMID: 23376231 Free PMC article.

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